Effect of hematoporphyrin derivative photoradiation therapy on survival in the rat 9L gliosarcoma brain-tumor model

James E Boggan, C. Bolger, M. S B Edwards

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Abstract

Intracerebral tumors were produced in 99 rats by stereotaxic implantation of 9L gliosarcoma brain-tumor cells. Hematoporphyrin derivative (HPD), 10 or 20 mg/kg, was administered as an intravenous bolus 24 or 48 hours before irradiation of the tumor region with light from an argon pumped-dye laser (632 nm). Laser light, at a dose of 30, 60, or 200 joules/sq cm, was delivered through a craniectomy 10 or 13 days after tumor implantation. Survival times were significantly prolonged in rats exposed to laser light at a dose of 200 joules/sq cm 24 hours after administration of HPD, 20 mg/kg.

Original languageEnglish (US)
Pages (from-to)917-921
Number of pages5
JournalJournal of Neurosurgery
Volume63
Issue number6
StatePublished - 1985

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ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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