Abstract
Intracerebral tumors were produced in 99 rats by stereotaxic implantation of 9L gliosarcoma brain-tumor cells. Hematoporphyrin derivative (HPD), 10 or 20 mg/kg, was administered as an intravenous bolus 24 or 48 hours before irradiation of the tumor region with light from an argon pumped-dye laser (632 nm). Laser light, at a dose of 30, 60, or 200 joules/sq cm, was delivered through a craniectomy 10 or 13 days after tumor implantation. Survival times were significantly prolonged in rats exposed to laser light at a dose of 200 joules/sq cm 24 hours after administration of HPD, 20 mg/kg.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 917-921 |
| Number of pages | 5 |
| Journal | Journal of Neurosurgery |
| Volume | 63 |
| Issue number | 6 |
| State | Published - 1985 |
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ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
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Effect of hematoporphyrin derivative photoradiation therapy on survival in the rat 9L gliosarcoma brain-tumor model. / Boggan, James E; Bolger, C.; Edwards, M. S B.
In: Journal of Neurosurgery, Vol. 63, No. 6, 1985, p. 917-921.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of hematoporphyrin derivative photoradiation therapy on survival in the rat 9L gliosarcoma brain-tumor model
AU - Boggan, James E
AU - Bolger, C.
AU - Edwards, M. S B
PY - 1985
Y1 - 1985
N2 - Intracerebral tumors were produced in 99 rats by stereotaxic implantation of 9L gliosarcoma brain-tumor cells. Hematoporphyrin derivative (HPD), 10 or 20 mg/kg, was administered as an intravenous bolus 24 or 48 hours before irradiation of the tumor region with light from an argon pumped-dye laser (632 nm). Laser light, at a dose of 30, 60, or 200 joules/sq cm, was delivered through a craniectomy 10 or 13 days after tumor implantation. Survival times were significantly prolonged in rats exposed to laser light at a dose of 200 joules/sq cm 24 hours after administration of HPD, 20 mg/kg.
AB - Intracerebral tumors were produced in 99 rats by stereotaxic implantation of 9L gliosarcoma brain-tumor cells. Hematoporphyrin derivative (HPD), 10 or 20 mg/kg, was administered as an intravenous bolus 24 or 48 hours before irradiation of the tumor region with light from an argon pumped-dye laser (632 nm). Laser light, at a dose of 30, 60, or 200 joules/sq cm, was delivered through a craniectomy 10 or 13 days after tumor implantation. Survival times were significantly prolonged in rats exposed to laser light at a dose of 200 joules/sq cm 24 hours after administration of HPD, 20 mg/kg.
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UR - http://www.scopus.com/inward/citedby.url?scp=0022379878&partnerID=8YFLogxK
M3 - Article
C2 - 2932542
AN - SCOPUS:0022379878
VL - 63
SP - 917
EP - 921
JO - Journal of Neurosurgery
JF - Journal of Neurosurgery
SN - 0022-3085
IS - 6
ER -