Effect of gonadotropin-releasing hormone on fertility in repeat-breeder California dairy cows

Robert Bondurant, I. Revah, C. Franti, R. J. Harman, D. Hird, D. Klingborg, M. McCloskey, L. Weaver, B. Wilgenberg

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

To assess the potential benefit to fertility from gonadotropin-releasing hormone (GnRH) administration to third service cows managed in typical California dairy systems, 963 cows were enlisted from 14 dairies served by 6 veterinary practices. The cows were randomly assigned to receive either GnRH (100 μg) or placebo at the time of the third artificial insemination. Fertility data were entered onto a proprietary microcomputer program common to all six practices, and collated independently by a third party. For the duration of the trial (1 yr), GnRH and placebo-treated cows had 43.2 and 39.3% conception rates, respectively (P=0.35). When treatments administered in summer months (July, August, September) were excluded, conception rates were 48.1 and 41.0%, respectively (P<0.1). The conception rates of cows treated with GnRH in August tended to be lower than those of placebo-treated cows (95% logarithmic confidence intervals of odds ratio = -1.139, 0.377). Between-herd variation in benefit from GnRH was evident, with two dairies showing no benefit, one dairy showing a negative effect, and four showing a range of effects from lightly beneficial to significantly beneficial. First-lactation cows did not benefit at any time from GnRH treatment. The data suggest that GnRH administered to third-service dairy cows under California conditions may result in increased conception rates in non-summer months, but that other unidentified variables may have important influence on the outcome of such treatment.

Original languageEnglish (US)
Pages (from-to)365-374
Number of pages10
JournalTheriogenology
Volume35
Issue number2
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

Fingerprint

gonadotropin-releasing hormone
Gonadotropin-Releasing Hormone
Fertility
dairy cows
cows
conception rate
dairies
placebos
Placebos
Artificial Insemination
microcomputers
Microcomputers
artificial insemination
Lactation
odds ratio
confidence interval
lactation
Odds Ratio
herds
Confidence Intervals

Keywords

  • conception rate
  • GnRH
  • infertility
  • repeat-breeder

ASJC Scopus subject areas

  • Small Animals
  • Food Animals
  • Animal Science and Zoology
  • Equine

Cite this

Bondurant, R., Revah, I., Franti, C., Harman, R. J., Hird, D., Klingborg, D., ... Wilgenberg, B. (1991). Effect of gonadotropin-releasing hormone on fertility in repeat-breeder California dairy cows. Theriogenology, 35(2), 365-374. https://doi.org/10.1016/0093-691X(91)90286-M

Effect of gonadotropin-releasing hormone on fertility in repeat-breeder California dairy cows. / Bondurant, Robert; Revah, I.; Franti, C.; Harman, R. J.; Hird, D.; Klingborg, D.; McCloskey, M.; Weaver, L.; Wilgenberg, B.

In: Theriogenology, Vol. 35, No. 2, 01.01.1991, p. 365-374.

Research output: Contribution to journalArticle

Bondurant, R, Revah, I, Franti, C, Harman, RJ, Hird, D, Klingborg, D, McCloskey, M, Weaver, L & Wilgenberg, B 1991, 'Effect of gonadotropin-releasing hormone on fertility in repeat-breeder California dairy cows', Theriogenology, vol. 35, no. 2, pp. 365-374. https://doi.org/10.1016/0093-691X(91)90286-M
Bondurant, Robert ; Revah, I. ; Franti, C. ; Harman, R. J. ; Hird, D. ; Klingborg, D. ; McCloskey, M. ; Weaver, L. ; Wilgenberg, B. / Effect of gonadotropin-releasing hormone on fertility in repeat-breeder California dairy cows. In: Theriogenology. 1991 ; Vol. 35, No. 2. pp. 365-374.
@article{1730e6a4c5524dc1a02ff3ebeb66c2b0,
title = "Effect of gonadotropin-releasing hormone on fertility in repeat-breeder California dairy cows",
abstract = "To assess the potential benefit to fertility from gonadotropin-releasing hormone (GnRH) administration to third service cows managed in typical California dairy systems, 963 cows were enlisted from 14 dairies served by 6 veterinary practices. The cows were randomly assigned to receive either GnRH (100 μg) or placebo at the time of the third artificial insemination. Fertility data were entered onto a proprietary microcomputer program common to all six practices, and collated independently by a third party. For the duration of the trial (1 yr), GnRH and placebo-treated cows had 43.2 and 39.3{\%} conception rates, respectively (P=0.35). When treatments administered in summer months (July, August, September) were excluded, conception rates were 48.1 and 41.0{\%}, respectively (P<0.1). The conception rates of cows treated with GnRH in August tended to be lower than those of placebo-treated cows (95{\%} logarithmic confidence intervals of odds ratio = -1.139, 0.377). Between-herd variation in benefit from GnRH was evident, with two dairies showing no benefit, one dairy showing a negative effect, and four showing a range of effects from lightly beneficial to significantly beneficial. First-lactation cows did not benefit at any time from GnRH treatment. The data suggest that GnRH administered to third-service dairy cows under California conditions may result in increased conception rates in non-summer months, but that other unidentified variables may have important influence on the outcome of such treatment.",
keywords = "conception rate, GnRH, infertility, repeat-breeder",
author = "Robert Bondurant and I. Revah and C. Franti and Harman, {R. J.} and D. Hird and D. Klingborg and M. McCloskey and L. Weaver and B. Wilgenberg",
year = "1991",
month = "1",
day = "1",
doi = "10.1016/0093-691X(91)90286-M",
language = "English (US)",
volume = "35",
pages = "365--374",
journal = "Theriogenology",
issn = "0093-691X",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Effect of gonadotropin-releasing hormone on fertility in repeat-breeder California dairy cows

AU - Bondurant, Robert

AU - Revah, I.

AU - Franti, C.

AU - Harman, R. J.

AU - Hird, D.

AU - Klingborg, D.

AU - McCloskey, M.

AU - Weaver, L.

AU - Wilgenberg, B.

PY - 1991/1/1

Y1 - 1991/1/1

N2 - To assess the potential benefit to fertility from gonadotropin-releasing hormone (GnRH) administration to third service cows managed in typical California dairy systems, 963 cows were enlisted from 14 dairies served by 6 veterinary practices. The cows were randomly assigned to receive either GnRH (100 μg) or placebo at the time of the third artificial insemination. Fertility data were entered onto a proprietary microcomputer program common to all six practices, and collated independently by a third party. For the duration of the trial (1 yr), GnRH and placebo-treated cows had 43.2 and 39.3% conception rates, respectively (P=0.35). When treatments administered in summer months (July, August, September) were excluded, conception rates were 48.1 and 41.0%, respectively (P<0.1). The conception rates of cows treated with GnRH in August tended to be lower than those of placebo-treated cows (95% logarithmic confidence intervals of odds ratio = -1.139, 0.377). Between-herd variation in benefit from GnRH was evident, with two dairies showing no benefit, one dairy showing a negative effect, and four showing a range of effects from lightly beneficial to significantly beneficial. First-lactation cows did not benefit at any time from GnRH treatment. The data suggest that GnRH administered to third-service dairy cows under California conditions may result in increased conception rates in non-summer months, but that other unidentified variables may have important influence on the outcome of such treatment.

AB - To assess the potential benefit to fertility from gonadotropin-releasing hormone (GnRH) administration to third service cows managed in typical California dairy systems, 963 cows were enlisted from 14 dairies served by 6 veterinary practices. The cows were randomly assigned to receive either GnRH (100 μg) or placebo at the time of the third artificial insemination. Fertility data were entered onto a proprietary microcomputer program common to all six practices, and collated independently by a third party. For the duration of the trial (1 yr), GnRH and placebo-treated cows had 43.2 and 39.3% conception rates, respectively (P=0.35). When treatments administered in summer months (July, August, September) were excluded, conception rates were 48.1 and 41.0%, respectively (P<0.1). The conception rates of cows treated with GnRH in August tended to be lower than those of placebo-treated cows (95% logarithmic confidence intervals of odds ratio = -1.139, 0.377). Between-herd variation in benefit from GnRH was evident, with two dairies showing no benefit, one dairy showing a negative effect, and four showing a range of effects from lightly beneficial to significantly beneficial. First-lactation cows did not benefit at any time from GnRH treatment. The data suggest that GnRH administered to third-service dairy cows under California conditions may result in increased conception rates in non-summer months, but that other unidentified variables may have important influence on the outcome of such treatment.

KW - conception rate

KW - GnRH

KW - infertility

KW - repeat-breeder

UR - http://www.scopus.com/inward/record.url?scp=0345288450&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0345288450&partnerID=8YFLogxK

U2 - 10.1016/0093-691X(91)90286-M

DO - 10.1016/0093-691X(91)90286-M

M3 - Article

VL - 35

SP - 365

EP - 374

JO - Theriogenology

JF - Theriogenology

SN - 0093-691X

IS - 2

ER -