Abstract
Glucocorticoid therapy is the most common cause of secondary iatrogenic osteoporosis. The bone loss occurs predominantly due to a decrease in bone formation, although increased bone resorption also occurs. Glucocorticoids induce osteoblast apoptosis and increase osteoclast survival and activity. Most of these effects are mediated through the RANKL/OPG system but perturbations in gonadal hormone activity and calcium balance may also contribute significantly to bone loss. Future therapies in the treatment and prevention of glucocorticoid-induced osteoporosis may be targeted at restoring the hormonal and cytokine balance to nullify the apoptotic effect of glucocorticoids on bone forming cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 212-216 |
| Number of pages | 5 |
| Journal | Medical and Pediatric Oncology |
| Volume | 41 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 1 2003 |
| Externally published | Yes |
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Keywords
- Bone growth
- Glucocorticoids
- Osteoclasts
- Osteoporosis
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Oncology
- Cancer Research
Cite this
Effect of glucocorticoids on bone density. / Rehman, Qaiser; Lane, Nancy E.
In: Medical and Pediatric Oncology, Vol. 41, No. 3, 01.09.2003, p. 212-216.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of glucocorticoids on bone density
AU - Rehman, Qaiser
AU - Lane, Nancy E
PY - 2003/9/1
Y1 - 2003/9/1
N2 - Glucocorticoid therapy is the most common cause of secondary iatrogenic osteoporosis. The bone loss occurs predominantly due to a decrease in bone formation, although increased bone resorption also occurs. Glucocorticoids induce osteoblast apoptosis and increase osteoclast survival and activity. Most of these effects are mediated through the RANKL/OPG system but perturbations in gonadal hormone activity and calcium balance may also contribute significantly to bone loss. Future therapies in the treatment and prevention of glucocorticoid-induced osteoporosis may be targeted at restoring the hormonal and cytokine balance to nullify the apoptotic effect of glucocorticoids on bone forming cells.
AB - Glucocorticoid therapy is the most common cause of secondary iatrogenic osteoporosis. The bone loss occurs predominantly due to a decrease in bone formation, although increased bone resorption also occurs. Glucocorticoids induce osteoblast apoptosis and increase osteoclast survival and activity. Most of these effects are mediated through the RANKL/OPG system but perturbations in gonadal hormone activity and calcium balance may also contribute significantly to bone loss. Future therapies in the treatment and prevention of glucocorticoid-induced osteoporosis may be targeted at restoring the hormonal and cytokine balance to nullify the apoptotic effect of glucocorticoids on bone forming cells.
KW - Bone growth
KW - Glucocorticoids
KW - Osteoclasts
KW - Osteoporosis
UR - http://www.scopus.com/inward/record.url?scp=0042844488&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0042844488&partnerID=8YFLogxK
U2 - 10.1002/mpo.10339
DO - 10.1002/mpo.10339
M3 - Article
C2 - 12868121
AN - SCOPUS:0042844488
VL - 41
SP - 212
EP - 216
JO - Pediatric Blood and Cancer
JF - Pediatric Blood and Cancer
SN - 1545-5009
IS - 3
ER -