Effect of general anesthesia in infancy on long-term recognition memory in humans and rats

Greg Stratmann, Joshua Lee, Jeffrey W. Sall, Bradley H. Lee, Rehan S. Alvi, Jennifer Shih, Allison M. Rowe, Tatiana M. Ramage, Flora L. Chang, Terri G. Alexander, David K. Lempert, Nan Lin, Kasey H. Siu, Sophie A. Elphick, Alice Wong, Caitlin I. Schnair, Alexander F. Vu, John T. Chan, Huizhen Zai, Michelle K. Wong & 14 others Amanda M. Anthony, Kyle C. Barbour, Dana Ben-Tzur, Natalie E. Kazarian, Joyce Y Y Lee, Jay R. Shen, Eric Liu, Gurbir S. Behniwal, Cathleen R Lammers, Zoel Quinones, Anuj Aggarwal, Elizabeth Cedars, Andrew P. Yonelinas, Simona Ghetti

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Anesthesia in infancy impairs performance in recognition memory tasks in mammalian animals, but it is unknown if this occurs in humans. Successful recognition can be based on stimulus familiarity or recollection of event details. Several brain structures involved in recollection are affected by anesthesia-induced neurodegeneration in animals. Therefore, we hypothesized that anesthesia in infancy impairs recollection later in life in humans and rats. Twenty eight children ages 6-11 who had undergone a procedure requiring general anesthesia before age 1 were compared with 28 age- and gender-matched children who had not undergone anesthesia. Recollection and familiarity were assessed in an object recognition memory test using receiver operator characteristic analysis. In addition, IQ and Child Behavior Checklist scores were assessed. In parallel, thirty three 7-day-old rats were randomized to receive anesthesia or sham anesthesia. Over 10 months, recollection and familiarity were assessed using an odor recognition test. We found that anesthetized children had significantly lower recollection scores and were impaired at recollecting associative information compared with controls. Familiarity, IQ, and Child Behavior Checklist scores were not different between groups. In rats, anesthetized subjects had significantly lower recollection scores than controls while familiarity was unaffected. Rats that had undergone tissue injury during anesthesia had similar recollection indices as rats that had been anesthetized without tissue injury. These findings suggest that general anesthesia in infancy impairs recollection later in life in humans and rats. In rats, this effect is independent of underlying disease or tissue injury.

Original languageEnglish (US)
Pages (from-to)2275-2287
Number of pages13
JournalNeuropsychopharmacology
Volume39
Issue number10
DOIs
StatePublished - 2014

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Long-Term Memory
General Anesthesia
Anesthesia
Child Behavior
Checklist
Wounds and Injuries
Recognition (Psychology)
Brain

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Medicine(all)

Cite this

Stratmann, G., Lee, J., Sall, J. W., Lee, B. H., Alvi, R. S., Shih, J., ... Ghetti, S. (2014). Effect of general anesthesia in infancy on long-term recognition memory in humans and rats. Neuropsychopharmacology, 39(10), 2275-2287. https://doi.org/10.1038/npp.2014.134

Effect of general anesthesia in infancy on long-term recognition memory in humans and rats. / Stratmann, Greg; Lee, Joshua; Sall, Jeffrey W.; Lee, Bradley H.; Alvi, Rehan S.; Shih, Jennifer; Rowe, Allison M.; Ramage, Tatiana M.; Chang, Flora L.; Alexander, Terri G.; Lempert, David K.; Lin, Nan; Siu, Kasey H.; Elphick, Sophie A.; Wong, Alice; Schnair, Caitlin I.; Vu, Alexander F.; Chan, John T.; Zai, Huizhen; Wong, Michelle K.; Anthony, Amanda M.; Barbour, Kyle C.; Ben-Tzur, Dana; Kazarian, Natalie E.; Lee, Joyce Y Y; Shen, Jay R.; Liu, Eric; Behniwal, Gurbir S.; Lammers, Cathleen R; Quinones, Zoel; Aggarwal, Anuj; Cedars, Elizabeth; Yonelinas, Andrew P.; Ghetti, Simona.

In: Neuropsychopharmacology, Vol. 39, No. 10, 2014, p. 2275-2287.

Research output: Contribution to journalArticle

Stratmann, G, Lee, J, Sall, JW, Lee, BH, Alvi, RS, Shih, J, Rowe, AM, Ramage, TM, Chang, FL, Alexander, TG, Lempert, DK, Lin, N, Siu, KH, Elphick, SA, Wong, A, Schnair, CI, Vu, AF, Chan, JT, Zai, H, Wong, MK, Anthony, AM, Barbour, KC, Ben-Tzur, D, Kazarian, NE, Lee, JYY, Shen, JR, Liu, E, Behniwal, GS, Lammers, CR, Quinones, Z, Aggarwal, A, Cedars, E, Yonelinas, AP & Ghetti, S 2014, 'Effect of general anesthesia in infancy on long-term recognition memory in humans and rats', Neuropsychopharmacology, vol. 39, no. 10, pp. 2275-2287. https://doi.org/10.1038/npp.2014.134
Stratmann, Greg ; Lee, Joshua ; Sall, Jeffrey W. ; Lee, Bradley H. ; Alvi, Rehan S. ; Shih, Jennifer ; Rowe, Allison M. ; Ramage, Tatiana M. ; Chang, Flora L. ; Alexander, Terri G. ; Lempert, David K. ; Lin, Nan ; Siu, Kasey H. ; Elphick, Sophie A. ; Wong, Alice ; Schnair, Caitlin I. ; Vu, Alexander F. ; Chan, John T. ; Zai, Huizhen ; Wong, Michelle K. ; Anthony, Amanda M. ; Barbour, Kyle C. ; Ben-Tzur, Dana ; Kazarian, Natalie E. ; Lee, Joyce Y Y ; Shen, Jay R. ; Liu, Eric ; Behniwal, Gurbir S. ; Lammers, Cathleen R ; Quinones, Zoel ; Aggarwal, Anuj ; Cedars, Elizabeth ; Yonelinas, Andrew P. ; Ghetti, Simona. / Effect of general anesthesia in infancy on long-term recognition memory in humans and rats. In: Neuropsychopharmacology. 2014 ; Vol. 39, No. 10. pp. 2275-2287.
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AU - Shih, Jennifer

AU - Rowe, Allison M.

AU - Ramage, Tatiana M.

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AU - Alexander, Terri G.

AU - Lempert, David K.

AU - Lin, Nan

AU - Siu, Kasey H.

AU - Elphick, Sophie A.

AU - Wong, Alice

AU - Schnair, Caitlin I.

AU - Vu, Alexander F.

AU - Chan, John T.

AU - Zai, Huizhen

AU - Wong, Michelle K.

AU - Anthony, Amanda M.

AU - Barbour, Kyle C.

AU - Ben-Tzur, Dana

AU - Kazarian, Natalie E.

AU - Lee, Joyce Y Y

AU - Shen, Jay R.

AU - Liu, Eric

AU - Behniwal, Gurbir S.

AU - Lammers, Cathleen R

AU - Quinones, Zoel

AU - Aggarwal, Anuj

AU - Cedars, Elizabeth

AU - Yonelinas, Andrew P.

AU - Ghetti, Simona

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