Abstract
Objective-To characterize the effect of general anesthesia and minor surgery on renal function in horses. Animals-9 mares with a mean (± SE) age and body weight of 9 ± 2 years and 492 ± 17 kg, respectively. Procedure-The day before anesthesia, urine was collected (catheterization) for 3 hours to quantitate baseline values, and serum biochemical analysis was performed. The following day, xylazine (1.1 mg/kg, IV) was administered, and general anesthesia was induced 5 minutes later with diazepam (0.04 mg/kg, IV) and ketamine (2.2 mg/kg, IV). During 2 hours of anesthesia with isoflurane, Paco2 was maintained between 48 and 52 mm Hg, and mean arterial blood pressure was between 70 and 80 mm Hg. Blood and urine were collected at 30, 60, and 120 minutes during and at 1 hour after anesthesia. Results-Baseline urine flow was 0.92 ± 0.17 ml/kg/h and significantly increased at 30 and 60 minutes after xylazine administration (2.14 ± 0.59 and 2.86 ± 0.97 ml/kg/h respectively) but returned to baseline values by the end of anesthesia. Serum glucose concentration increased from 12 ± 4 to 167 ± 8 mg/dl at 30 minutes. Glucosuria was not observed. Conclusions and Clinical Relevance-Transient hyperglycemia and an increase in rine production accompanies a commonly used anesthetic technique for horses. The increase in urine flow is not trivial and should be considered in anesthetic management decisions. With the exception of serum glucose concentration and urine production, the effect of general anesthesia on indices of renal function in clinically normal horses is likely of little consequence in most horses admitted for elective surgical procedures.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1061-1065 |
| Number of pages | 5 |
| Journal | American Journal of Veterinary Research |
| Volume | 63 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jan 1 2002 |
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ASJC Scopus subject areas
- veterinary(all)
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Effect of general anesthesia and minor surgical trauma on urine and serum measurements in horses. / Watson, Zara E.; Steffey, Eugene; VanHoogmoed, Linda M.; Snyder, Jack R.
In: American Journal of Veterinary Research, Vol. 63, No. 7, 01.01.2002, p. 1061-1065.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of general anesthesia and minor surgical trauma on urine and serum measurements in horses
AU - Watson, Zara E.
AU - Steffey, Eugene
AU - VanHoogmoed, Linda M.
AU - Snyder, Jack R.
PY - 2002/1/1
Y1 - 2002/1/1
N2 - Objective-To characterize the effect of general anesthesia and minor surgery on renal function in horses. Animals-9 mares with a mean (± SE) age and body weight of 9 ± 2 years and 492 ± 17 kg, respectively. Procedure-The day before anesthesia, urine was collected (catheterization) for 3 hours to quantitate baseline values, and serum biochemical analysis was performed. The following day, xylazine (1.1 mg/kg, IV) was administered, and general anesthesia was induced 5 minutes later with diazepam (0.04 mg/kg, IV) and ketamine (2.2 mg/kg, IV). During 2 hours of anesthesia with isoflurane, Paco2 was maintained between 48 and 52 mm Hg, and mean arterial blood pressure was between 70 and 80 mm Hg. Blood and urine were collected at 30, 60, and 120 minutes during and at 1 hour after anesthesia. Results-Baseline urine flow was 0.92 ± 0.17 ml/kg/h and significantly increased at 30 and 60 minutes after xylazine administration (2.14 ± 0.59 and 2.86 ± 0.97 ml/kg/h respectively) but returned to baseline values by the end of anesthesia. Serum glucose concentration increased from 12 ± 4 to 167 ± 8 mg/dl at 30 minutes. Glucosuria was not observed. Conclusions and Clinical Relevance-Transient hyperglycemia and an increase in rine production accompanies a commonly used anesthetic technique for horses. The increase in urine flow is not trivial and should be considered in anesthetic management decisions. With the exception of serum glucose concentration and urine production, the effect of general anesthesia on indices of renal function in clinically normal horses is likely of little consequence in most horses admitted for elective surgical procedures.
AB - Objective-To characterize the effect of general anesthesia and minor surgery on renal function in horses. Animals-9 mares with a mean (± SE) age and body weight of 9 ± 2 years and 492 ± 17 kg, respectively. Procedure-The day before anesthesia, urine was collected (catheterization) for 3 hours to quantitate baseline values, and serum biochemical analysis was performed. The following day, xylazine (1.1 mg/kg, IV) was administered, and general anesthesia was induced 5 minutes later with diazepam (0.04 mg/kg, IV) and ketamine (2.2 mg/kg, IV). During 2 hours of anesthesia with isoflurane, Paco2 was maintained between 48 and 52 mm Hg, and mean arterial blood pressure was between 70 and 80 mm Hg. Blood and urine were collected at 30, 60, and 120 minutes during and at 1 hour after anesthesia. Results-Baseline urine flow was 0.92 ± 0.17 ml/kg/h and significantly increased at 30 and 60 minutes after xylazine administration (2.14 ± 0.59 and 2.86 ± 0.97 ml/kg/h respectively) but returned to baseline values by the end of anesthesia. Serum glucose concentration increased from 12 ± 4 to 167 ± 8 mg/dl at 30 minutes. Glucosuria was not observed. Conclusions and Clinical Relevance-Transient hyperglycemia and an increase in rine production accompanies a commonly used anesthetic technique for horses. The increase in urine flow is not trivial and should be considered in anesthetic management decisions. With the exception of serum glucose concentration and urine production, the effect of general anesthesia on indices of renal function in clinically normal horses is likely of little consequence in most horses admitted for elective surgical procedures.
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UR - http://www.scopus.com/inward/citedby.url?scp=0035985532&partnerID=8YFLogxK
U2 - 10.2460/ajvr.2002.63.1061
DO - 10.2460/ajvr.2002.63.1061
M3 - Article
C2 - 12118669
AN - SCOPUS:0035985532
VL - 63
SP - 1061
EP - 1065
JO - American Journal of Veterinary Research
JF - American Journal of Veterinary Research
SN - 0002-9645
IS - 7
ER -