Abstract
Plasma endogenous adrenocorticotropic hormone (ACTH) concentrations as well as basal and post-ACTH-stimulation plasma cortisol concentrations were measured in 6 dogs ultimately shown to have hyperfunctioning adrenocortical tumors. The basal and post-ACTH-stimulation plasma cortisol concentrations were found to fluctuate in 4 dogs in which repeat studies were done. Three dogs had at least 1 normal and 1 abnormally high plasma cortisol concentration after exogenous ACTH administration. A 4th dog had 1 normal and 1 abnormally high resting cortisol concentration. One dog tested twice 3 days apart had similar test results each time and a 6th dog was tested once. All of the dots had at least 1 plasma endogenous ACTH concentration greater than 2 standard deviations below the normal mean. All endogenous ACTH concentrations were less than those previously reported for dogs with pituitary-dependent hyperadrenocorticism. The results indicated that the diagnosis of adrenocortical tumor cannot reliably be made on the basis of the plasma cortisol response to exogenous ACTH; however, the use of plasma endogenous ACTH determination can be an important diagnostic aid.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 823-826 |
| Number of pages | 4 |
| Journal | Journal of the American Veterinary Medical Association |
| Volume | 178 |
| Issue number | 8 |
| State | Published - Apr 15 1981 |
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ASJC Scopus subject areas
- veterinary(all)
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Effect of functional adrenocortical tumors on plasma cortisol and corticotropin concentrations in dogs. / Feldman, E. C.
In: Journal of the American Veterinary Medical Association, Vol. 178, No. 8, 15.04.1981, p. 823-826.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of functional adrenocortical tumors on plasma cortisol and corticotropin concentrations in dogs.
AU - Feldman, E. C.
PY - 1981/4/15
Y1 - 1981/4/15
N2 - Plasma endogenous adrenocorticotropic hormone (ACTH) concentrations as well as basal and post-ACTH-stimulation plasma cortisol concentrations were measured in 6 dogs ultimately shown to have hyperfunctioning adrenocortical tumors. The basal and post-ACTH-stimulation plasma cortisol concentrations were found to fluctuate in 4 dogs in which repeat studies were done. Three dogs had at least 1 normal and 1 abnormally high plasma cortisol concentration after exogenous ACTH administration. A 4th dog had 1 normal and 1 abnormally high resting cortisol concentration. One dog tested twice 3 days apart had similar test results each time and a 6th dog was tested once. All of the dots had at least 1 plasma endogenous ACTH concentration greater than 2 standard deviations below the normal mean. All endogenous ACTH concentrations were less than those previously reported for dogs with pituitary-dependent hyperadrenocorticism. The results indicated that the diagnosis of adrenocortical tumor cannot reliably be made on the basis of the plasma cortisol response to exogenous ACTH; however, the use of plasma endogenous ACTH determination can be an important diagnostic aid.
AB - Plasma endogenous adrenocorticotropic hormone (ACTH) concentrations as well as basal and post-ACTH-stimulation plasma cortisol concentrations were measured in 6 dogs ultimately shown to have hyperfunctioning adrenocortical tumors. The basal and post-ACTH-stimulation plasma cortisol concentrations were found to fluctuate in 4 dogs in which repeat studies were done. Three dogs had at least 1 normal and 1 abnormally high plasma cortisol concentration after exogenous ACTH administration. A 4th dog had 1 normal and 1 abnormally high resting cortisol concentration. One dog tested twice 3 days apart had similar test results each time and a 6th dog was tested once. All of the dots had at least 1 plasma endogenous ACTH concentration greater than 2 standard deviations below the normal mean. All endogenous ACTH concentrations were less than those previously reported for dogs with pituitary-dependent hyperadrenocorticism. The results indicated that the diagnosis of adrenocortical tumor cannot reliably be made on the basis of the plasma cortisol response to exogenous ACTH; however, the use of plasma endogenous ACTH determination can be an important diagnostic aid.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019880720&partnerID=8YFLogxK
M3 - Article
C2 - 6268586
AN - SCOPUS:0019880720
VL - 178
SP - 823
EP - 826
JO - Journal of the American Veterinary Medical Association
JF - Journal of the American Veterinary Medical Association
SN - 0003-1488
IS - 8
ER -