Effect of Exercise on Serum Estrogens in Postmenopausal Women: A 12-Month Randomized Clinical Trial

Anne McTiernan, Shelley S. Tworoger, Cornelia M. Ulrich, Yutaka Yasui, Melinda L. Irwin, Kumar Rajan, Bess Sorensen, Rebecca E. Rudolph, Deborah Bowen, Frank Z. Stanczyk, John D. Potter, Robert S. Schwartz

Research output: Contribution to journalArticle

240 Citations (Scopus)

Abstract

Elevated circulating estrogens and a sedentary lifestyle increase risk for breast cancer. The effect of exercise on circulating estrogens in sedentary postmenopausal women is unknown. The objective of this study was to examine the effects of a 12-month moderate-intensity exercise intervention on serum estrogens. We randomly assigned 173 sedentary, overweight (body mass index > 24.0 kg/m2, body fat > 33%), postmenopausal women, ages 50-75 years, not using hormone therapy, living in the Seattle, Washington, area for the next year, and willing to be randomly assigned to an exercise intervention or stretching control group. The exercise intervention included facility and home-based exercise (45 min, 5 days/ week moderate intensity sports/ recreational exercise). A total of 170 (98.3%) women completed the study with exercisers averaging 171 min/ week of exercise. After 3 months, exercisers experienced declines in estrone, estradiol, and free estradiol of 3.8, 7.7, and 8.2%, respectively, versus no change or increased concentrations in controls (P = 0.03, 0.07, and 0.02, respectively). At 12 months, the direction of effect remained the same, although the differences were no longer statistically significant. The effect was limited to women who lost body fat: women whose percentage of body fat [by dual energy x-ray absortiometry (DEXA)] decreased by ≥2% had statistically significant (comparing exercisers versus controls) decreases at 12 months of 11.9, 13.7, and 16.7% for serum estrone, estradiol, and free estradiol, respectively. We concluded that a 12-month moderate-intensity exercise intervention in postmenopausal women resulted in significant decreases in serum estrogens. The association between increased physical activity and reduced risk for postmenopausal breast cancer may be partly explained by effects on serum estrogens.

Original languageEnglish (US)
Pages (from-to)2923-2928
Number of pages6
JournalCancer Research
Volume64
Issue number8
DOIs
StatePublished - Apr 15 2004
Externally publishedYes

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compound A 12
Estrogens
Randomized Controlled Trials
Exercise
Serum
Estradiol
Adipose Tissue
Estrone
Breast Neoplasms
Sedentary Lifestyle
Sports
Body Mass Index
X-Rays
Hormones
Control Groups

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

McTiernan, A., Tworoger, S. S., Ulrich, C. M., Yasui, Y., Irwin, M. L., Rajan, K., ... Schwartz, R. S. (2004). Effect of Exercise on Serum Estrogens in Postmenopausal Women: A 12-Month Randomized Clinical Trial. Cancer Research, 64(8), 2923-2928. https://doi.org/10.1158/0008-5472.CAN-03-3393

Effect of Exercise on Serum Estrogens in Postmenopausal Women : A 12-Month Randomized Clinical Trial. / McTiernan, Anne; Tworoger, Shelley S.; Ulrich, Cornelia M.; Yasui, Yutaka; Irwin, Melinda L.; Rajan, Kumar; Sorensen, Bess; Rudolph, Rebecca E.; Bowen, Deborah; Stanczyk, Frank Z.; Potter, John D.; Schwartz, Robert S.

In: Cancer Research, Vol. 64, No. 8, 15.04.2004, p. 2923-2928.

Research output: Contribution to journalArticle

McTiernan, A, Tworoger, SS, Ulrich, CM, Yasui, Y, Irwin, ML, Rajan, K, Sorensen, B, Rudolph, RE, Bowen, D, Stanczyk, FZ, Potter, JD & Schwartz, RS 2004, 'Effect of Exercise on Serum Estrogens in Postmenopausal Women: A 12-Month Randomized Clinical Trial', Cancer Research, vol. 64, no. 8, pp. 2923-2928. https://doi.org/10.1158/0008-5472.CAN-03-3393
McTiernan, Anne ; Tworoger, Shelley S. ; Ulrich, Cornelia M. ; Yasui, Yutaka ; Irwin, Melinda L. ; Rajan, Kumar ; Sorensen, Bess ; Rudolph, Rebecca E. ; Bowen, Deborah ; Stanczyk, Frank Z. ; Potter, John D. ; Schwartz, Robert S. / Effect of Exercise on Serum Estrogens in Postmenopausal Women : A 12-Month Randomized Clinical Trial. In: Cancer Research. 2004 ; Vol. 64, No. 8. pp. 2923-2928.
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