Abstract
Four groups of five kittens each were individually fed for 6 wk either a purified control diet containing 0.5% methionine (Met) (based on 18% casein supplemented with arginine, cystine and threonine) or one of three experimental diets containing an additional 2, 3 or 4% L-Met. The diets with added Met caused a reduction in food intake (FI) on the second day and a negative body weight gain (BWG), in proportion to the level of added Met. After 10 d, kittens fed the 2 and 3% Met diets increased their FI and had positive BWG. During the last 10 d of the experiment, the control, 2% Met and 3% Met groups had BWG of 28, 15 and 0 g/d, respectively. Kittens given the 4% Met diet showed no adaptation and continued to lose weight. In these kittens plasma concentration of Met was 50-70 times and cystathionine about three times greater than in control kittens. Four male kittens were fed the same 4% Met diet for 6 wk and then switched to a diet containing 4% L-Met plus 4% glycine (Gly) for 12 d. Average daily FI was 21.4 ± 1.3 g with 4% Met and 48.5 ± 2.5 g after the addition of Gly, and BWG went from negative to positive. These results indicate that growing kittens are more sensitive than rats to excess Met and have a limited adaptive capacity. Kittens did not grow normally when the diet contained 2% or more dietary Met, which was equivalent to 0.6 g Met (kg body wt·d).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1838-1843 |
| Number of pages | 6 |
| Journal | Journal of Nutrition |
| Volume | 117 |
| Issue number | 11 |
| DOIs | |
| State | Published - Jan 1 1987 |
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ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
Cite this
Effect of excess dietary methionine on weight gain and plasma amino acids in kittens. / Fau, D.; Smalley, K. A.; Morris, James; Rogers, Quinton.
In: Journal of Nutrition, Vol. 117, No. 11, 01.01.1987, p. 1838-1843.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of excess dietary methionine on weight gain and plasma amino acids in kittens
AU - Fau, D.
AU - Smalley, K. A.
AU - Morris, James
AU - Rogers, Quinton
PY - 1987/1/1
Y1 - 1987/1/1
N2 - Four groups of five kittens each were individually fed for 6 wk either a purified control diet containing 0.5% methionine (Met) (based on 18% casein supplemented with arginine, cystine and threonine) or one of three experimental diets containing an additional 2, 3 or 4% L-Met. The diets with added Met caused a reduction in food intake (FI) on the second day and a negative body weight gain (BWG), in proportion to the level of added Met. After 10 d, kittens fed the 2 and 3% Met diets increased their FI and had positive BWG. During the last 10 d of the experiment, the control, 2% Met and 3% Met groups had BWG of 28, 15 and 0 g/d, respectively. Kittens given the 4% Met diet showed no adaptation and continued to lose weight. In these kittens plasma concentration of Met was 50-70 times and cystathionine about three times greater than in control kittens. Four male kittens were fed the same 4% Met diet for 6 wk and then switched to a diet containing 4% L-Met plus 4% glycine (Gly) for 12 d. Average daily FI was 21.4 ± 1.3 g with 4% Met and 48.5 ± 2.5 g after the addition of Gly, and BWG went from negative to positive. These results indicate that growing kittens are more sensitive than rats to excess Met and have a limited adaptive capacity. Kittens did not grow normally when the diet contained 2% or more dietary Met, which was equivalent to 0.6 g Met (kg body wt·d).
AB - Four groups of five kittens each were individually fed for 6 wk either a purified control diet containing 0.5% methionine (Met) (based on 18% casein supplemented with arginine, cystine and threonine) or one of three experimental diets containing an additional 2, 3 or 4% L-Met. The diets with added Met caused a reduction in food intake (FI) on the second day and a negative body weight gain (BWG), in proportion to the level of added Met. After 10 d, kittens fed the 2 and 3% Met diets increased their FI and had positive BWG. During the last 10 d of the experiment, the control, 2% Met and 3% Met groups had BWG of 28, 15 and 0 g/d, respectively. Kittens given the 4% Met diet showed no adaptation and continued to lose weight. In these kittens plasma concentration of Met was 50-70 times and cystathionine about three times greater than in control kittens. Four male kittens were fed the same 4% Met diet for 6 wk and then switched to a diet containing 4% L-Met plus 4% glycine (Gly) for 12 d. Average daily FI was 21.4 ± 1.3 g with 4% Met and 48.5 ± 2.5 g after the addition of Gly, and BWG went from negative to positive. These results indicate that growing kittens are more sensitive than rats to excess Met and have a limited adaptive capacity. Kittens did not grow normally when the diet contained 2% or more dietary Met, which was equivalent to 0.6 g Met (kg body wt·d).
UR - http://www.scopus.com/inward/record.url?scp=0023579980&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023579980&partnerID=8YFLogxK
U2 - 10.1093/jn/117.11.1838
DO - 10.1093/jn/117.11.1838
M3 - Article
C2 - 3681474
AN - SCOPUS:0023579980
VL - 117
SP - 1838
EP - 1843
JO - Journal of Nutrition
JF - Journal of Nutrition
SN - 0022-3166
IS - 11
ER -