## Abstract

Statistically based iterative image reconstruction methods have been developed for emission tomography. One important component in iterative image reconstruction is the system matrix, which defines the mapping from the image space to the data space. Several groups have demonstrated that an accurate system matrix can improve image quality in both single photon emission computed tomography (SPECT) and positron emission tomography (PET). While iterative methods are amenable to arbitrary and complicated system models, the true system response is never known exactly. In practice, one also has to sacrifice the accuracy of the system model because of limited computing and imaging resources. This paper analyses the effect of errors in the system matrix on iterative image reconstruction methods that are based on the maximum a posteriori principle. We derived an analytical expression for calculating artefacts in a reconstructed image that are caused by errors in the system matrix using the first-order Taylor series approximation. The theoretical expression is used to determine the required minimum accuracy of the system matrix in emission tomography. Computer simulations show that the theoretical results work reasonably well in low-noise situations.

Original language | English (US) |
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Pages (from-to) | 3297-3312 |

Number of pages | 16 |

Journal | Physics in Medicine and Biology |

Volume | 50 |

Issue number | 14 |

DOIs | |

State | Published - Jul 21 2005 |

## ASJC Scopus subject areas

- Biomedical Engineering
- Physics and Astronomy (miscellaneous)
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology