Effect of epsilon amino caproic acid on experimental acetic acid colitis

Nirmal S Mann, H. C. Kwaan, Surinder K Mann, E. C. Cheung

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

In the present rat model, intracolonic administration of 10% acetic acid produced diffuse chemical colitis. The animals were serially sacrificed at 24 hours, 3 days, 1 week, 4 weeks and 8 weeks after the application of acetic acid. Marked hyperemia and ulceration appeared at 24 hours and the ulcers were covered with yellow plaque at 1 week. Histologically there was coagulative necrosis, vascular congestion, ulceration, infiltration with inflammatory cells and formation of crypt abscesses. These changes subsided by 8 weeks. Concomitant intracolonic administration of epsilon amino caproic acid (E.A.C.A.) protected the colonic mucosa against this chemical insult. Plasminogen activator (fibrinolytic) activity was determined on the colonic tissues. Topical application of acetic acid markedly increased the colonic mucosal fibrinolytic activity. The protective effect of E.A.C.A. was related to the decrease in the acetic acid-induced fibrinolytic activity in the colonic tissue. This animal model of experimental chemical colitis may be useful in evaluating the efficacy and mechanism of action of other therapeutic agents.

Original languageEnglish (US)
Title of host publicationAmerican Journal of Proctology Gastroenterology and Colon and Rectal Surgery
Pages11-18
Number of pages8
Volume31
Edition4
StatePublished - 1980
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mann, N. S., Kwaan, H. C., Mann, S. K., & Cheung, E. C. (1980). Effect of epsilon amino caproic acid on experimental acetic acid colitis. In American Journal of Proctology Gastroenterology and Colon and Rectal Surgery (4 ed., Vol. 31, pp. 11-18)