Effect of distribution of solid and liquid lipid domains on transport of free radicals in nanostructured lipid carriers

Sharifa Davis, Janhavi Haldipur, Yuan Zhao, Nily Dan, Yuanjie Pan, Nitin Nitin, Rohan V. Tikekar

Research output: Contribution to journalArticle

5 Scopus citations


Peroxyl radical sensitive fluorescent dye (BODIPY 665/676) encapsulated nanostructured lipid carriers (NLCs) were prepared by blending solid (eicosane) and liquid (glyceryl trioctanoate) lipid in various proportions (10:90, 30:70, 50:50, 100:0 liquid: solid). Peroxyl radical transport rate was measured by adding 20 mmol/l 2,2'-azobis-2-methyl-propanimidamide, dihydrochloride in the aqueous phase. Fluorescence imaging of NLCs revealed that fluorescent dye was distributed in the liquid lipid regions of 10 and 30% NLCs. However, 50% NLC resembled NLCs with 100% liquid lipid in that, little or no solid domains were observed and the dye was more or less uniformly distributed. Peroxyl radical transport was in the order, 100% < 50% < 30% < 10% NLCs. More uniform distribution of the encapsulant possibly reduced the effective peroxyl radical transport rate, particularly when solid domains were present in the core of NLCs. Thus, 100% liquid lipid emulsions may be better than NLCs in improving the oxidative stability of the encapsulant.

Original languageEnglish (US)
Pages (from-to)14-17
Number of pages4
JournalLWT - Food Science and Technology
Issue number1
StatePublished - 2015



  • Encapsulation
  • Nanostructured lipid carriers
  • Peroxyl radicals

ASJC Scopus subject areas

  • Food Science

Cite this