Effect of distribution of solid and liquid lipid domains on transport of free radicals in nanostructured lipid carriers

Sharifa Davis, Janhavi Haldipur, Yuan Zhao, Nily Dan, Yuanjie Pan, Nitin Nitin, Rohan V. Tikekar

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Peroxyl radical sensitive fluorescent dye (BODIPY 665/676) encapsulated nanostructured lipid carriers (NLCs) were prepared by blending solid (eicosane) and liquid (glyceryl trioctanoate) lipid in various proportions (10:90, 30:70, 50:50, 100:0 liquid: solid). Peroxyl radical transport rate was measured by adding 20 mmol/l 2,2'-azobis-2-methyl-propanimidamide, dihydrochloride in the aqueous phase. Fluorescence imaging of NLCs revealed that fluorescent dye was distributed in the liquid lipid regions of 10 and 30% NLCs. However, 50% NLC resembled NLCs with 100% liquid lipid in that, little or no solid domains were observed and the dye was more or less uniformly distributed. Peroxyl radical transport was in the order, 100% < 50% < 30% < 10% NLCs. More uniform distribution of the encapsulant possibly reduced the effective peroxyl radical transport rate, particularly when solid domains were present in the core of NLCs. Thus, 100% liquid lipid emulsions may be better than NLCs in improving the oxidative stability of the encapsulant.

Original languageEnglish (US)
Pages (from-to)14-17
Number of pages4
JournalLWT - Food Science and Technology
Volume64
Issue number1
DOIs
StatePublished - 2015

Fingerprint

Free Radicals
Lipids
liquids
lipids
fluorescent dyes
Fluorescent Dyes
Optical Imaging
oxidative stability
Emulsions
emulsions
dyes
Coloring Agents
image analysis
fluorescence
perhydroxyl radical

Keywords

  • Encapsulation
  • Nanostructured lipid carriers
  • Peroxyl radicals

ASJC Scopus subject areas

  • Food Science

Cite this

Effect of distribution of solid and liquid lipid domains on transport of free radicals in nanostructured lipid carriers. / Davis, Sharifa; Haldipur, Janhavi; Zhao, Yuan; Dan, Nily; Pan, Yuanjie; Nitin, Nitin; Tikekar, Rohan V.

In: LWT - Food Science and Technology, Vol. 64, No. 1, 2015, p. 14-17.

Research output: Contribution to journalArticle

Davis, Sharifa ; Haldipur, Janhavi ; Zhao, Yuan ; Dan, Nily ; Pan, Yuanjie ; Nitin, Nitin ; Tikekar, Rohan V. / Effect of distribution of solid and liquid lipid domains on transport of free radicals in nanostructured lipid carriers. In: LWT - Food Science and Technology. 2015 ; Vol. 64, No. 1. pp. 14-17.
@article{3877dc0eeb2d4ffca3fb6ff5e7137eb3,
title = "Effect of distribution of solid and liquid lipid domains on transport of free radicals in nanostructured lipid carriers",
abstract = "Peroxyl radical sensitive fluorescent dye (BODIPY 665/676) encapsulated nanostructured lipid carriers (NLCs) were prepared by blending solid (eicosane) and liquid (glyceryl trioctanoate) lipid in various proportions (10:90, 30:70, 50:50, 100:0 liquid: solid). Peroxyl radical transport rate was measured by adding 20 mmol/l 2,2'-azobis-2-methyl-propanimidamide, dihydrochloride in the aqueous phase. Fluorescence imaging of NLCs revealed that fluorescent dye was distributed in the liquid lipid regions of 10 and 30{\%} NLCs. However, 50{\%} NLC resembled NLCs with 100{\%} liquid lipid in that, little or no solid domains were observed and the dye was more or less uniformly distributed. Peroxyl radical transport was in the order, 100{\%} < 50{\%} < 30{\%} < 10{\%} NLCs. More uniform distribution of the encapsulant possibly reduced the effective peroxyl radical transport rate, particularly when solid domains were present in the core of NLCs. Thus, 100{\%} liquid lipid emulsions may be better than NLCs in improving the oxidative stability of the encapsulant.",
keywords = "Encapsulation, Nanostructured lipid carriers, Peroxyl radicals",
author = "Sharifa Davis and Janhavi Haldipur and Yuan Zhao and Nily Dan and Yuanjie Pan and Nitin Nitin and Tikekar, {Rohan V.}",
year = "2015",
doi = "10.1016/j.lwt.2015.05.013",
language = "English (US)",
volume = "64",
pages = "14--17",
journal = "LWT - Food Science and Technology",
issn = "0023-6438",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Effect of distribution of solid and liquid lipid domains on transport of free radicals in nanostructured lipid carriers

AU - Davis, Sharifa

AU - Haldipur, Janhavi

AU - Zhao, Yuan

AU - Dan, Nily

AU - Pan, Yuanjie

AU - Nitin, Nitin

AU - Tikekar, Rohan V.

PY - 2015

Y1 - 2015

N2 - Peroxyl radical sensitive fluorescent dye (BODIPY 665/676) encapsulated nanostructured lipid carriers (NLCs) were prepared by blending solid (eicosane) and liquid (glyceryl trioctanoate) lipid in various proportions (10:90, 30:70, 50:50, 100:0 liquid: solid). Peroxyl radical transport rate was measured by adding 20 mmol/l 2,2'-azobis-2-methyl-propanimidamide, dihydrochloride in the aqueous phase. Fluorescence imaging of NLCs revealed that fluorescent dye was distributed in the liquid lipid regions of 10 and 30% NLCs. However, 50% NLC resembled NLCs with 100% liquid lipid in that, little or no solid domains were observed and the dye was more or less uniformly distributed. Peroxyl radical transport was in the order, 100% < 50% < 30% < 10% NLCs. More uniform distribution of the encapsulant possibly reduced the effective peroxyl radical transport rate, particularly when solid domains were present in the core of NLCs. Thus, 100% liquid lipid emulsions may be better than NLCs in improving the oxidative stability of the encapsulant.

AB - Peroxyl radical sensitive fluorescent dye (BODIPY 665/676) encapsulated nanostructured lipid carriers (NLCs) were prepared by blending solid (eicosane) and liquid (glyceryl trioctanoate) lipid in various proportions (10:90, 30:70, 50:50, 100:0 liquid: solid). Peroxyl radical transport rate was measured by adding 20 mmol/l 2,2'-azobis-2-methyl-propanimidamide, dihydrochloride in the aqueous phase. Fluorescence imaging of NLCs revealed that fluorescent dye was distributed in the liquid lipid regions of 10 and 30% NLCs. However, 50% NLC resembled NLCs with 100% liquid lipid in that, little or no solid domains were observed and the dye was more or less uniformly distributed. Peroxyl radical transport was in the order, 100% < 50% < 30% < 10% NLCs. More uniform distribution of the encapsulant possibly reduced the effective peroxyl radical transport rate, particularly when solid domains were present in the core of NLCs. Thus, 100% liquid lipid emulsions may be better than NLCs in improving the oxidative stability of the encapsulant.

KW - Encapsulation

KW - Nanostructured lipid carriers

KW - Peroxyl radicals

UR - http://www.scopus.com/inward/record.url?scp=84953875236&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84953875236&partnerID=8YFLogxK

U2 - 10.1016/j.lwt.2015.05.013

DO - 10.1016/j.lwt.2015.05.013

M3 - Article

AN - SCOPUS:84953875236

VL - 64

SP - 14

EP - 17

JO - LWT - Food Science and Technology

JF - LWT - Food Science and Technology

SN - 0023-6438

IS - 1

ER -