Effect of dioctyl sodium sulfosuccinate feeding on rat colorectal 1,2-dimethylhydrazine carcinogenesis

D. A. Karlin, Robert T O'Donnell, W. E. Jensen

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The 1,2-dimethylhydrazine (DMH) rodent model for colorectal carcinogenesis was used to explore the effect of dietary dioctyl sodium sulfosuccinate (DSS) on carcinogenesis. Inbred male F344 rats were divided into two groups of 84 each and fed the following diets: ground chow and 5% corn oil (control group) and ground chow, 5% corn oil, and 1% DSS (experimental group). All rats received high-dose DMH base, 20 mg/kg/week sc for 20 weeks. Twenty rats per group were killed after 3, 4, 5, and 6 months. Duodenum, small intestine, colon, and rectum were dissected out. Each tumor was measured for size and location and evaluated histologically. The percentage of rats bearing tumors in the control and experimental groups did not differ significantly. In each rat there were fewer gastrointestinal tumors in the DSS-fed group of all histologic types combined, at all organ sites, at 5 and 6 months. This difference between the control and DSS-fed rats reached the level of statistical significance for tumors of the duodenum, colon, and rectum and for total gastrointestinal tumors at the 5th month.

Original languageEnglish (US)
Pages (from-to)791-793
Number of pages3
JournalJournal of the National Cancer Institute
Volume64
Issue number4
StatePublished - 1980
Externally publishedYes

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Dioctyl Sulfosuccinic Acid
1,2-Dimethylhydrazine
Carcinogenesis
Corn Oil
Neoplasms
Duodenum
Rectum
Colon
Dietary Sodium
Control Groups
Inbred F344 Rats
Small Intestine
Rodentia
Diet

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Effect of dioctyl sodium sulfosuccinate feeding on rat colorectal 1,2-dimethylhydrazine carcinogenesis. / Karlin, D. A.; O'Donnell, Robert T; Jensen, W. E.

In: Journal of the National Cancer Institute, Vol. 64, No. 4, 1980, p. 791-793.

Research output: Contribution to journalArticle

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abstract = "The 1,2-dimethylhydrazine (DMH) rodent model for colorectal carcinogenesis was used to explore the effect of dietary dioctyl sodium sulfosuccinate (DSS) on carcinogenesis. Inbred male F344 rats were divided into two groups of 84 each and fed the following diets: ground chow and 5{\%} corn oil (control group) and ground chow, 5{\%} corn oil, and 1{\%} DSS (experimental group). All rats received high-dose DMH base, 20 mg/kg/week sc for 20 weeks. Twenty rats per group were killed after 3, 4, 5, and 6 months. Duodenum, small intestine, colon, and rectum were dissected out. Each tumor was measured for size and location and evaluated histologically. The percentage of rats bearing tumors in the control and experimental groups did not differ significantly. In each rat there were fewer gastrointestinal tumors in the DSS-fed group of all histologic types combined, at all organ sites, at 5 and 6 months. This difference between the control and DSS-fed rats reached the level of statistical significance for tumors of the duodenum, colon, and rectum and for total gastrointestinal tumors at the 5th month.",
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