Effect of dietary triglycerides on lymphocyte transformation in rats

C. K. Clifford, L. M. Smith, Kent L Erickson, C. L. Hamblin, R. K. Creveling, A. J. Clifford

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Weanling rats were fed casein-based diets containing purified and mixed triglycerides to evaluate the effect of these lipids on mitogen-induced lymphocyte transformation, lymphoid organ weights, and fatty acid profiles of the total lipid in plasma, spleen, and thymus. Test lipids were added at a level of 8 g per 100 g of diet. All diets contained 0.82 g of safflower oil per 100 g. The digestibility coefficients for tristearin, tripalmitin, and trimyristin were 20, 37, and 85%, respectively. Digestibility coefficients for all remaining triglycerides were 90% or greater. The differences in mitogen-induced lymphocyte transformation among rats fed the various dietary lipids were unrelated to saturation of the lipid and correlated negatively with total lipid absorbed. Except for tripalmitin and tristearin, dietary lipids significantly altered the fatty acid profiles of the total lipids in plasma, spleen and thymus. It was concluded that the fatty acid profiles of the total lipid in plasma, spleen and thymus can be altered without accompanying major changes in mitogen-induced blood lymphocyte transformation. It was further concluded that mitogen-induced lymphocyte transformation was unrelated to saturation of dietary lipid and appeared to be associated negatively and weakly with the quantity of dietary lipid absorbed.

Original languageEnglish (US)
Pages (from-to)669-679
Number of pages11
JournalJournal of Nutrition
Volume113
Issue number3
StatePublished - 1983

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lymphocyte proliferation
Lymphocyte Activation
dietary fat
Triglycerides
triacylglycerols
tripalmitin
blood lipids
Lipids
spleen
fatty acid composition
rats
lipids
digestibility
diet
Mitogens
safflower oil
tissue weight
Thymus Gland
weanlings
Fatty Acids

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Clifford, C. K., Smith, L. M., Erickson, K. L., Hamblin, C. L., Creveling, R. K., & Clifford, A. J. (1983). Effect of dietary triglycerides on lymphocyte transformation in rats. Journal of Nutrition, 113(3), 669-679.

Effect of dietary triglycerides on lymphocyte transformation in rats. / Clifford, C. K.; Smith, L. M.; Erickson, Kent L; Hamblin, C. L.; Creveling, R. K.; Clifford, A. J.

In: Journal of Nutrition, Vol. 113, No. 3, 1983, p. 669-679.

Research output: Contribution to journalArticle

Clifford, CK, Smith, LM, Erickson, KL, Hamblin, CL, Creveling, RK & Clifford, AJ 1983, 'Effect of dietary triglycerides on lymphocyte transformation in rats', Journal of Nutrition, vol. 113, no. 3, pp. 669-679.
Clifford CK, Smith LM, Erickson KL, Hamblin CL, Creveling RK, Clifford AJ. Effect of dietary triglycerides on lymphocyte transformation in rats. Journal of Nutrition. 1983;113(3):669-679.
Clifford, C. K. ; Smith, L. M. ; Erickson, Kent L ; Hamblin, C. L. ; Creveling, R. K. ; Clifford, A. J. / Effect of dietary triglycerides on lymphocyte transformation in rats. In: Journal of Nutrition. 1983 ; Vol. 113, No. 3. pp. 669-679.
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