Effect of dietary starch, fat, and bicarbonate content on exercise responses and serum creatine kinase activity in equine recurrent exertional rhabdomyolysis

Erica C. McKenzie, Stephanie J. Valberg, Sandra M. Godden, Joe D. Pagan, Jennifer M. MacLeay, Ray J. Geor, Gary Carlson

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

To determine the effect of dietary starch, bicarbonate, and fat content on metabolic responses and serum creatine kinase (CK) activity in exercising Thoroughbreds with recurrent exertional rhabdomyolysis (RER), 5 RER horses were fed 3 isocaloric diets (28.8 Mcal/d [120.5 MJ/d]) for 3 weeks in a crossover design and exercised for 30 minutes on a treadmill 5 days/wk. On the last day of each diet, an incremental standardized exercise test (SET) was performed. The starch diet contained 40% digestible energy (DE) as starch and 5% as fat; the bicarbonate-starch diet was identical but was supplemented with sodium bicarbonate (4.2% of the pellet); and the fat diet provided 7% DE as starch and 20% as fat. Serum CK activity before the SET was similar among the diets. Serum CK activity (log transformed) after submaximal exercise differed dramatically among the diets and was greatest on the bicarbonate-starch diet (6.51 ± 1.5) and lowest on the fat diet (5.71 ± 0.6). Appreciable differences were observed in the severity of RER among individual horses. Postexercise plasma pH, bicarbonate concentration, and lactate concentration did not differ among the diets. Resting heart rates before the SET were markedly lower on the fat diet than on the starch diet. Muscle lactate and glycogen concentrations before and after the SET did not differ markedly among the diets. A high-fat, low-starch diet results in dramatically lower postexercise CK activity in severely affected RER horses than does a low-fat, high-starch diet without measurably altering muscle lactate and glycogen concentrations. Dietary bicarbonate supplementation at the concentration administered in this study did not prevent increased serum CK activity on a high-starch diet.

Original languageEnglish (US)
Pages (from-to)693-701
Number of pages9
JournalJournal of Veterinary Internal Medicine
Volume17
Issue number5
DOIs
StatePublished - Sep 1 2003

Fingerprint

rhabdomyolysis
Rhabdomyolysis
dietary carbohydrate
Dietary Fats
creatine kinase
Creatine Kinase
Bicarbonates
bicarbonates
Starch
Horses
exercise
Diet
horses
lipids
Serum
diet
starch
Exercise Test
exercise test
Fats

Keywords

  • Exertional myopathy
  • Horse
  • Nutrition
  • Tying up

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Effect of dietary starch, fat, and bicarbonate content on exercise responses and serum creatine kinase activity in equine recurrent exertional rhabdomyolysis. / McKenzie, Erica C.; Valberg, Stephanie J.; Godden, Sandra M.; Pagan, Joe D.; MacLeay, Jennifer M.; Geor, Ray J.; Carlson, Gary.

In: Journal of Veterinary Internal Medicine, Vol. 17, No. 5, 01.09.2003, p. 693-701.

Research output: Contribution to journalArticle

McKenzie, Erica C. ; Valberg, Stephanie J. ; Godden, Sandra M. ; Pagan, Joe D. ; MacLeay, Jennifer M. ; Geor, Ray J. ; Carlson, Gary. / Effect of dietary starch, fat, and bicarbonate content on exercise responses and serum creatine kinase activity in equine recurrent exertional rhabdomyolysis. In: Journal of Veterinary Internal Medicine. 2003 ; Vol. 17, No. 5. pp. 693-701.
@article{48543c0a96b542829f03cdd31bcc912c,
title = "Effect of dietary starch, fat, and bicarbonate content on exercise responses and serum creatine kinase activity in equine recurrent exertional rhabdomyolysis",
abstract = "To determine the effect of dietary starch, bicarbonate, and fat content on metabolic responses and serum creatine kinase (CK) activity in exercising Thoroughbreds with recurrent exertional rhabdomyolysis (RER), 5 RER horses were fed 3 isocaloric diets (28.8 Mcal/d [120.5 MJ/d]) for 3 weeks in a crossover design and exercised for 30 minutes on a treadmill 5 days/wk. On the last day of each diet, an incremental standardized exercise test (SET) was performed. The starch diet contained 40{\%} digestible energy (DE) as starch and 5{\%} as fat; the bicarbonate-starch diet was identical but was supplemented with sodium bicarbonate (4.2{\%} of the pellet); and the fat diet provided 7{\%} DE as starch and 20{\%} as fat. Serum CK activity before the SET was similar among the diets. Serum CK activity (log transformed) after submaximal exercise differed dramatically among the diets and was greatest on the bicarbonate-starch diet (6.51 ± 1.5) and lowest on the fat diet (5.71 ± 0.6). Appreciable differences were observed in the severity of RER among individual horses. Postexercise plasma pH, bicarbonate concentration, and lactate concentration did not differ among the diets. Resting heart rates before the SET were markedly lower on the fat diet than on the starch diet. Muscle lactate and glycogen concentrations before and after the SET did not differ markedly among the diets. A high-fat, low-starch diet results in dramatically lower postexercise CK activity in severely affected RER horses than does a low-fat, high-starch diet without measurably altering muscle lactate and glycogen concentrations. Dietary bicarbonate supplementation at the concentration administered in this study did not prevent increased serum CK activity on a high-starch diet.",
keywords = "Exertional myopathy, Horse, Nutrition, Tying up",
author = "McKenzie, {Erica C.} and Valberg, {Stephanie J.} and Godden, {Sandra M.} and Pagan, {Joe D.} and MacLeay, {Jennifer M.} and Geor, {Ray J.} and Gary Carlson",
year = "2003",
month = "9",
day = "1",
doi = "10.1892/0891-6640(2003)017<0693:EODSFA>2.3.CO;2",
language = "English (US)",
volume = "17",
pages = "693--701",
journal = "Journal of Veterinary Internal Medicine",
issn = "0891-6640",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Effect of dietary starch, fat, and bicarbonate content on exercise responses and serum creatine kinase activity in equine recurrent exertional rhabdomyolysis

AU - McKenzie, Erica C.

AU - Valberg, Stephanie J.

AU - Godden, Sandra M.

AU - Pagan, Joe D.

AU - MacLeay, Jennifer M.

AU - Geor, Ray J.

AU - Carlson, Gary

PY - 2003/9/1

Y1 - 2003/9/1

N2 - To determine the effect of dietary starch, bicarbonate, and fat content on metabolic responses and serum creatine kinase (CK) activity in exercising Thoroughbreds with recurrent exertional rhabdomyolysis (RER), 5 RER horses were fed 3 isocaloric diets (28.8 Mcal/d [120.5 MJ/d]) for 3 weeks in a crossover design and exercised for 30 minutes on a treadmill 5 days/wk. On the last day of each diet, an incremental standardized exercise test (SET) was performed. The starch diet contained 40% digestible energy (DE) as starch and 5% as fat; the bicarbonate-starch diet was identical but was supplemented with sodium bicarbonate (4.2% of the pellet); and the fat diet provided 7% DE as starch and 20% as fat. Serum CK activity before the SET was similar among the diets. Serum CK activity (log transformed) after submaximal exercise differed dramatically among the diets and was greatest on the bicarbonate-starch diet (6.51 ± 1.5) and lowest on the fat diet (5.71 ± 0.6). Appreciable differences were observed in the severity of RER among individual horses. Postexercise plasma pH, bicarbonate concentration, and lactate concentration did not differ among the diets. Resting heart rates before the SET were markedly lower on the fat diet than on the starch diet. Muscle lactate and glycogen concentrations before and after the SET did not differ markedly among the diets. A high-fat, low-starch diet results in dramatically lower postexercise CK activity in severely affected RER horses than does a low-fat, high-starch diet without measurably altering muscle lactate and glycogen concentrations. Dietary bicarbonate supplementation at the concentration administered in this study did not prevent increased serum CK activity on a high-starch diet.

AB - To determine the effect of dietary starch, bicarbonate, and fat content on metabolic responses and serum creatine kinase (CK) activity in exercising Thoroughbreds with recurrent exertional rhabdomyolysis (RER), 5 RER horses were fed 3 isocaloric diets (28.8 Mcal/d [120.5 MJ/d]) for 3 weeks in a crossover design and exercised for 30 minutes on a treadmill 5 days/wk. On the last day of each diet, an incremental standardized exercise test (SET) was performed. The starch diet contained 40% digestible energy (DE) as starch and 5% as fat; the bicarbonate-starch diet was identical but was supplemented with sodium bicarbonate (4.2% of the pellet); and the fat diet provided 7% DE as starch and 20% as fat. Serum CK activity before the SET was similar among the diets. Serum CK activity (log transformed) after submaximal exercise differed dramatically among the diets and was greatest on the bicarbonate-starch diet (6.51 ± 1.5) and lowest on the fat diet (5.71 ± 0.6). Appreciable differences were observed in the severity of RER among individual horses. Postexercise plasma pH, bicarbonate concentration, and lactate concentration did not differ among the diets. Resting heart rates before the SET were markedly lower on the fat diet than on the starch diet. Muscle lactate and glycogen concentrations before and after the SET did not differ markedly among the diets. A high-fat, low-starch diet results in dramatically lower postexercise CK activity in severely affected RER horses than does a low-fat, high-starch diet without measurably altering muscle lactate and glycogen concentrations. Dietary bicarbonate supplementation at the concentration administered in this study did not prevent increased serum CK activity on a high-starch diet.

KW - Exertional myopathy

KW - Horse

KW - Nutrition

KW - Tying up

UR - http://www.scopus.com/inward/record.url?scp=0141923889&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141923889&partnerID=8YFLogxK

U2 - 10.1892/0891-6640(2003)017<0693:EODSFA>2.3.CO;2

DO - 10.1892/0891-6640(2003)017<0693:EODSFA>2.3.CO;2

M3 - Article

C2 - 14529137

AN - SCOPUS:0141923889

VL - 17

SP - 693

EP - 701

JO - Journal of Veterinary Internal Medicine

JF - Journal of Veterinary Internal Medicine

SN - 0891-6640

IS - 5

ER -