Effect of dietary n-3 polyunsaturated fatty acids on plasma total and high-molecular-weight adiponectin concentrations in overweight to moderately obese men and women

Mario Kratz, Michael M. Swarbrick, Holly S. Callahan, Colleen C. Matthys, Peter J Havel, David S. Weigle

Research output: Contribution to journalArticle

67 Scopus citations

Abstract

Background: Recent studies indicated that dietary n-3 polyunsaturated fatty acids (PUFAs) increase circulating adiponectin concentrations in rodents. Objective: We aimed to investigate whether a diet rich in n-3 PUFAs increased plasma concentrations of total or high-molecular-weight (HMW) adiponectin in healthy overweight-to-moderately obese men and women. Design: Sixteen women and 10 men with a body mass index (in kg/m2) between 28 and 33 were randomly assigned to consume a diet rich in n-3 PUFAs (3.5% of energy intake) from both plant and marine sources or a control diet (0.5% of energy intake from n-3 PUFAs). For the first 2 wk, these diets were consumed under isocaloric conditions; then followed a 12-wk period of ad libitum consumption that was associated with a moderate loss of ≈3.5% of body weight in both groups. Total and HMW adiponectin plasma concentrations were measured before and after each diet phase. Results: Plasma fasting adiponectin concentrations did not change during the isocaloric period, but they increased modestly (≈10%) during the ad libitum period when subjects lost weight [P = 0.009 for time in repeated-measures analysis of variance] and to a similar extent in subjects consuming the control (x- ± SD: 0.42 ± 0.69 μg/mL) and n-3 PUFA (0.45 ± 0.85 μg/mL) diets (P = 0.920 for time x treatment interaction). Plasma concentrations of HMW adiponectin did not change significantly during the study. Conclusion: Dietary n-3 PUFAs consumed at levels of 3.5% of energy intake do not significantly increase plasma or HMW adiponectin concentrations in overweight-to-moderately obese healthy men and women over the course of 14 wk.

Original languageEnglish (US)
Pages (from-to)347-353
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume87
Issue number2
StatePublished - Jan 2 2008

Keywords

  • Adiponectin
  • Diet
  • Fatty acids
  • Humans
  • N-3
  • Obesity
  • Omega-3
  • Overweight

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

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