Effect of dietary n-3 polyunsaturated fatty acids on plasma total and high-molecular-weight adiponectin concentrations in overweight to moderately obese men and women

Mario Kratz, Michael M. Swarbrick, Holly S. Callahan, Colleen C. Matthys, Peter J Havel, David S. Weigle

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Background: Recent studies indicated that dietary n-3 polyunsaturated fatty acids (PUFAs) increase circulating adiponectin concentrations in rodents. Objective: We aimed to investigate whether a diet rich in n-3 PUFAs increased plasma concentrations of total or high-molecular-weight (HMW) adiponectin in healthy overweight-to-moderately obese men and women. Design: Sixteen women and 10 men with a body mass index (in kg/m2) between 28 and 33 were randomly assigned to consume a diet rich in n-3 PUFAs (3.5% of energy intake) from both plant and marine sources or a control diet (0.5% of energy intake from n-3 PUFAs). For the first 2 wk, these diets were consumed under isocaloric conditions; then followed a 12-wk period of ad libitum consumption that was associated with a moderate loss of ≈3.5% of body weight in both groups. Total and HMW adiponectin plasma concentrations were measured before and after each diet phase. Results: Plasma fasting adiponectin concentrations did not change during the isocaloric period, but they increased modestly (≈10%) during the ad libitum period when subjects lost weight [P = 0.009 for time in repeated-measures analysis of variance] and to a similar extent in subjects consuming the control (x- ± SD: 0.42 ± 0.69 μg/mL) and n-3 PUFA (0.45 ± 0.85 μg/mL) diets (P = 0.920 for time x treatment interaction). Plasma concentrations of HMW adiponectin did not change significantly during the study. Conclusion: Dietary n-3 PUFAs consumed at levels of 3.5% of energy intake do not significantly increase plasma or HMW adiponectin concentrations in overweight-to-moderately obese healthy men and women over the course of 14 wk.

Original languageEnglish (US)
Pages (from-to)347-353
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume87
Issue number2
StatePublished - Jan 2 2008

Fingerprint

adiponectin
Adiponectin
Omega-3 Fatty Acids
omega-3 fatty acids
polyunsaturated fatty acids
Molecular Weight
molecular weight
Diet
Energy Intake
diet
energy intake
diet study techniques
fasting
body mass index
Rodentia
Fasting
Analysis of Variance
Body Mass Index
rodents
analysis of variance

Keywords

  • Adiponectin
  • Diet
  • Fatty acids
  • Humans
  • N-3
  • Obesity
  • Omega-3
  • Overweight

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Effect of dietary n-3 polyunsaturated fatty acids on plasma total and high-molecular-weight adiponectin concentrations in overweight to moderately obese men and women. / Kratz, Mario; Swarbrick, Michael M.; Callahan, Holly S.; Matthys, Colleen C.; Havel, Peter J; Weigle, David S.

In: American Journal of Clinical Nutrition, Vol. 87, No. 2, 02.01.2008, p. 347-353.

Research output: Contribution to journalArticle

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abstract = "Background: Recent studies indicated that dietary n-3 polyunsaturated fatty acids (PUFAs) increase circulating adiponectin concentrations in rodents. Objective: We aimed to investigate whether a diet rich in n-3 PUFAs increased plasma concentrations of total or high-molecular-weight (HMW) adiponectin in healthy overweight-to-moderately obese men and women. Design: Sixteen women and 10 men with a body mass index (in kg/m2) between 28 and 33 were randomly assigned to consume a diet rich in n-3 PUFAs (3.5{\%} of energy intake) from both plant and marine sources or a control diet (0.5{\%} of energy intake from n-3 PUFAs). For the first 2 wk, these diets were consumed under isocaloric conditions; then followed a 12-wk period of ad libitum consumption that was associated with a moderate loss of ≈3.5{\%} of body weight in both groups. Total and HMW adiponectin plasma concentrations were measured before and after each diet phase. Results: Plasma fasting adiponectin concentrations did not change during the isocaloric period, but they increased modestly (≈10{\%}) during the ad libitum period when subjects lost weight [P = 0.009 for time in repeated-measures analysis of variance] and to a similar extent in subjects consuming the control (x- ± SD: 0.42 ± 0.69 μg/mL) and n-3 PUFA (0.45 ± 0.85 μg/mL) diets (P = 0.920 for time x treatment interaction). Plasma concentrations of HMW adiponectin did not change significantly during the study. Conclusion: Dietary n-3 PUFAs consumed at levels of 3.5{\%} of energy intake do not significantly increase plasma or HMW adiponectin concentrations in overweight-to-moderately obese healthy men and women over the course of 14 wk.",
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T1 - Effect of dietary n-3 polyunsaturated fatty acids on plasma total and high-molecular-weight adiponectin concentrations in overweight to moderately obese men and women

AU - Kratz, Mario

AU - Swarbrick, Michael M.

AU - Callahan, Holly S.

AU - Matthys, Colleen C.

AU - Havel, Peter J

AU - Weigle, David S.

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N2 - Background: Recent studies indicated that dietary n-3 polyunsaturated fatty acids (PUFAs) increase circulating adiponectin concentrations in rodents. Objective: We aimed to investigate whether a diet rich in n-3 PUFAs increased plasma concentrations of total or high-molecular-weight (HMW) adiponectin in healthy overweight-to-moderately obese men and women. Design: Sixteen women and 10 men with a body mass index (in kg/m2) between 28 and 33 were randomly assigned to consume a diet rich in n-3 PUFAs (3.5% of energy intake) from both plant and marine sources or a control diet (0.5% of energy intake from n-3 PUFAs). For the first 2 wk, these diets were consumed under isocaloric conditions; then followed a 12-wk period of ad libitum consumption that was associated with a moderate loss of ≈3.5% of body weight in both groups. Total and HMW adiponectin plasma concentrations were measured before and after each diet phase. Results: Plasma fasting adiponectin concentrations did not change during the isocaloric period, but they increased modestly (≈10%) during the ad libitum period when subjects lost weight [P = 0.009 for time in repeated-measures analysis of variance] and to a similar extent in subjects consuming the control (x- ± SD: 0.42 ± 0.69 μg/mL) and n-3 PUFA (0.45 ± 0.85 μg/mL) diets (P = 0.920 for time x treatment interaction). Plasma concentrations of HMW adiponectin did not change significantly during the study. Conclusion: Dietary n-3 PUFAs consumed at levels of 3.5% of energy intake do not significantly increase plasma or HMW adiponectin concentrations in overweight-to-moderately obese healthy men and women over the course of 14 wk.

AB - Background: Recent studies indicated that dietary n-3 polyunsaturated fatty acids (PUFAs) increase circulating adiponectin concentrations in rodents. Objective: We aimed to investigate whether a diet rich in n-3 PUFAs increased plasma concentrations of total or high-molecular-weight (HMW) adiponectin in healthy overweight-to-moderately obese men and women. Design: Sixteen women and 10 men with a body mass index (in kg/m2) between 28 and 33 were randomly assigned to consume a diet rich in n-3 PUFAs (3.5% of energy intake) from both plant and marine sources or a control diet (0.5% of energy intake from n-3 PUFAs). For the first 2 wk, these diets were consumed under isocaloric conditions; then followed a 12-wk period of ad libitum consumption that was associated with a moderate loss of ≈3.5% of body weight in both groups. Total and HMW adiponectin plasma concentrations were measured before and after each diet phase. Results: Plasma fasting adiponectin concentrations did not change during the isocaloric period, but they increased modestly (≈10%) during the ad libitum period when subjects lost weight [P = 0.009 for time in repeated-measures analysis of variance] and to a similar extent in subjects consuming the control (x- ± SD: 0.42 ± 0.69 μg/mL) and n-3 PUFA (0.45 ± 0.85 μg/mL) diets (P = 0.920 for time x treatment interaction). Plasma concentrations of HMW adiponectin did not change significantly during the study. Conclusion: Dietary n-3 PUFAs consumed at levels of 3.5% of energy intake do not significantly increase plasma or HMW adiponectin concentrations in overweight-to-moderately obese healthy men and women over the course of 14 wk.

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KW - Obesity

KW - Omega-3

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