Effect of dietary linoleic acid level on lodgement, proliferation and survival of mammary tumor metastases

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

High levels of dietary linoleic acid (18 : 2) have been shown to increase the spontaneous metastasis of line 4526 mouse mammary tumors. In this report, the influence of 18 : 2 on specific events of tumor metastasis, namely, lodgement, proliferation and survival, were studied using spontaneous and experimental metastasis assays with line 4526 cells. A significantly greater number of radiolabeled tumor cells lodged in the lungs of mice fed 4, 8 and 12% 18 : 2 when compared with mice fed lower levels of 18 : 2. The effect of dietary 18 : 2 appeared to be on the host tissue (lungs) and not the tumor cells. Lodgement of tumor cells first cultured in serum of mice fed 18 : 2 then injected into mice fed 1% 18 : 2 was not affected. There were no significant differences in the percentage of [3H]thymidine labeled metastatic cells from lungs of mice fed different levels of 18 : 2. However, the number of surface lung nodules that appeared in mice 21 days after injection of unlabeled line 4526 cells increased in mice fed 8 and 12% 18 : 2 compared with those fed lower levels of 18 : 2. Thus, dietary 18 : 2 may increase metastasis by influencing the lodgement, implantation and survival but not proliferation of line 4526 mouse mammary tumor cells.

Original languageEnglish (US)
Pages (from-to)117-125
Number of pages9
JournalCancer Letters
Volume44
Issue number2
DOIs
StatePublished - 1989

Fingerprint

Linoleic Acid
Breast Neoplasms
Neoplasm Metastasis
Lung
Cultured Tumor Cells
Neoplasms
Thymidine
Injections
Serum

Keywords

  • dietary fat
  • linoleic acid
  • mammary tumors
  • metastasis

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

@article{32bf39829a314c4b88622cc517d47153,
title = "Effect of dietary linoleic acid level on lodgement, proliferation and survival of mammary tumor metastases",
abstract = "High levels of dietary linoleic acid (18 : 2) have been shown to increase the spontaneous metastasis of line 4526 mouse mammary tumors. In this report, the influence of 18 : 2 on specific events of tumor metastasis, namely, lodgement, proliferation and survival, were studied using spontaneous and experimental metastasis assays with line 4526 cells. A significantly greater number of radiolabeled tumor cells lodged in the lungs of mice fed 4, 8 and 12{\%} 18 : 2 when compared with mice fed lower levels of 18 : 2. The effect of dietary 18 : 2 appeared to be on the host tissue (lungs) and not the tumor cells. Lodgement of tumor cells first cultured in serum of mice fed 18 : 2 then injected into mice fed 1{\%} 18 : 2 was not affected. There were no significant differences in the percentage of [3H]thymidine labeled metastatic cells from lungs of mice fed different levels of 18 : 2. However, the number of surface lung nodules that appeared in mice 21 days after injection of unlabeled line 4526 cells increased in mice fed 8 and 12{\%} 18 : 2 compared with those fed lower levels of 18 : 2. Thus, dietary 18 : 2 may increase metastasis by influencing the lodgement, implantation and survival but not proliferation of line 4526 mouse mammary tumor cells.",
keywords = "dietary fat, linoleic acid, mammary tumors, metastasis",
author = "Neil Hubbard and Erickson, {Kent L}",
year = "1989",
doi = "10.1016/0304-3835(89)90006-2",
language = "English (US)",
volume = "44",
pages = "117--125",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Effect of dietary linoleic acid level on lodgement, proliferation and survival of mammary tumor metastases

AU - Hubbard, Neil

AU - Erickson, Kent L

PY - 1989

Y1 - 1989

N2 - High levels of dietary linoleic acid (18 : 2) have been shown to increase the spontaneous metastasis of line 4526 mouse mammary tumors. In this report, the influence of 18 : 2 on specific events of tumor metastasis, namely, lodgement, proliferation and survival, were studied using spontaneous and experimental metastasis assays with line 4526 cells. A significantly greater number of radiolabeled tumor cells lodged in the lungs of mice fed 4, 8 and 12% 18 : 2 when compared with mice fed lower levels of 18 : 2. The effect of dietary 18 : 2 appeared to be on the host tissue (lungs) and not the tumor cells. Lodgement of tumor cells first cultured in serum of mice fed 18 : 2 then injected into mice fed 1% 18 : 2 was not affected. There were no significant differences in the percentage of [3H]thymidine labeled metastatic cells from lungs of mice fed different levels of 18 : 2. However, the number of surface lung nodules that appeared in mice 21 days after injection of unlabeled line 4526 cells increased in mice fed 8 and 12% 18 : 2 compared with those fed lower levels of 18 : 2. Thus, dietary 18 : 2 may increase metastasis by influencing the lodgement, implantation and survival but not proliferation of line 4526 mouse mammary tumor cells.

AB - High levels of dietary linoleic acid (18 : 2) have been shown to increase the spontaneous metastasis of line 4526 mouse mammary tumors. In this report, the influence of 18 : 2 on specific events of tumor metastasis, namely, lodgement, proliferation and survival, were studied using spontaneous and experimental metastasis assays with line 4526 cells. A significantly greater number of radiolabeled tumor cells lodged in the lungs of mice fed 4, 8 and 12% 18 : 2 when compared with mice fed lower levels of 18 : 2. The effect of dietary 18 : 2 appeared to be on the host tissue (lungs) and not the tumor cells. Lodgement of tumor cells first cultured in serum of mice fed 18 : 2 then injected into mice fed 1% 18 : 2 was not affected. There were no significant differences in the percentage of [3H]thymidine labeled metastatic cells from lungs of mice fed different levels of 18 : 2. However, the number of surface lung nodules that appeared in mice 21 days after injection of unlabeled line 4526 cells increased in mice fed 8 and 12% 18 : 2 compared with those fed lower levels of 18 : 2. Thus, dietary 18 : 2 may increase metastasis by influencing the lodgement, implantation and survival but not proliferation of line 4526 mouse mammary tumor cells.

KW - dietary fat

KW - linoleic acid

KW - mammary tumors

KW - metastasis

UR - http://www.scopus.com/inward/record.url?scp=0024564674&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024564674&partnerID=8YFLogxK

U2 - 10.1016/0304-3835(89)90006-2

DO - 10.1016/0304-3835(89)90006-2

M3 - Article

VL - 44

SP - 117

EP - 125

JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

IS - 2

ER -