Effect of dietary limiting amino acid in prepyriform cortex on food intake

J. L. Beverly, D. W. Gietzen, Quinton Rogers

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The mechanisms underlying the reduced intake of an amino acid-imbalanced diet (imbalanced diet) appears to involve a decrease in the content of the dietary limiting amino acid (DLAA) in the prepyriform cortex (PPC). Intake of imbalanced diet was increased from 45-50 to 70-75% of baseline after bilateral injection of the DLAA directly into the PPC, following an inverted U-shaped dose-response curve. Injections had no effect on intake of basal diets. Injection of the DLAA into the PPC reversed the aversion to imbalanced diet in choice studies, as rats selected an imbalanced diet over protein-free diet after such injections. Intake of imbalanced diet did not increase after a nonlimiting amino acid was injected into the PPC or after injections of the DLAA into other brain areas. Results were similar when either threonine or isoleucine was the DLAA. These results confirm that the decrease in the concentration of the DLAA in the PPC is involved in the reduction in intake of imbalanced diets.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume259
Issue number4 28-4
StatePublished - Jan 1 1990

Fingerprint

Eating
Diet
Amino Acids
Injections
Protein-Restricted Diet
Piriform Cortex
Isoleucine
Threonine
Brain

Keywords

  • amino acid imbalance
  • food-intake regulation
  • intracerebral injection
  • isoleucine
  • rats
  • threonine

ASJC Scopus subject areas

  • Physiology

Cite this

Effect of dietary limiting amino acid in prepyriform cortex on food intake. / Beverly, J. L.; Gietzen, D. W.; Rogers, Quinton.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 259, No. 4 28-4, 01.01.1990.

Research output: Contribution to journalArticle

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