Effect of dietary catechin and vitamin E on aortic fatty streak accumulation in hypercholesterolemic hamsters

Ruping Xu, Wallace H. Yokoyama, Delilah Irving, Dietrich Rein, Rosemary L. Walzem, J. Bruce German

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Male golden Syrian hamsters were fed for 16 weeks on a hypercholesterolemic diet containing, per kg, 150 g of lipids (90 g butterfat, 35 g vitamin E-stripped corn oil and 25 g fish oil), 2 g cholesterol and either 3 IU vitamin E (3 IU E), 3 IU vitamin E and 200 mg catechin hydrate (3 IU E-200 Cat) or 30 IU vitamin E (30 IU E). More fatty streaks, measured by Oil Red O staining, were deposited in aortas of hamsters fed 3 IU E than in those fed either 3 IU E-200 Cat or 30 IU E. Lipid staining increased with plasma low-density lipoprotein cholesterol (LDL-C) in all animals. At the same concentration of LDL-C, animals fed either 3 IU E-200 Cat or 30 IU E developed less fatty streaks than those fed 3 IU E. Plasma, LDL-C and total cholesterol were highest in hamsters fed 3 IU E and LDL-C and total cholesterol in animals fed 3 IU-200 Cat were not different from those fed either 3 IU E or 30 IU E. This study showed the importance of circulating plasma LDL-C on atherogenesis and the inhibitory effect on this process of both dietary vitamin E and catechin.

Original languageEnglish (US)
Pages (from-to)29-36
Number of pages8
JournalAtherosclerosis
Volume137
Issue number1
DOIs
StatePublished - Mar 3 1998

Fingerprint

Catechin
Vitamin E
Cricetinae
LDL Cholesterol
Cats
Cholesterol
Staining and Labeling
Lipids
Corn Oil
Fish Oils
Mesocricetus
Aorta
Atherosclerosis

Keywords

  • Antioxidants
  • Atherosclerosis
  • Catechin
  • Fatty streak accumulation
  • Flavonoids
  • Hamsters
  • Lipoprotein cholesterol
  • Low density lipoproteins
  • Vitamin E

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Effect of dietary catechin and vitamin E on aortic fatty streak accumulation in hypercholesterolemic hamsters. / Xu, Ruping; Yokoyama, Wallace H.; Irving, Delilah; Rein, Dietrich; Walzem, Rosemary L.; German, J. Bruce.

In: Atherosclerosis, Vol. 137, No. 1, 03.03.1998, p. 29-36.

Research output: Contribution to journalArticle

Xu, Ruping ; Yokoyama, Wallace H. ; Irving, Delilah ; Rein, Dietrich ; Walzem, Rosemary L. ; German, J. Bruce. / Effect of dietary catechin and vitamin E on aortic fatty streak accumulation in hypercholesterolemic hamsters. In: Atherosclerosis. 1998 ; Vol. 137, No. 1. pp. 29-36.
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