Effect of dietary brussels sprouts with increased selenium content on mammary carcinogenesis in the rat

G. S. Stoewsand, J. L. Anderson, L. Munson, D. J. Lisk

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Brussels sprouts (Brassica oleracea, L; Jade cross E, hybrid cultivar) were cultivated with inorganic selenium added to the plant growth medium. Sprague-Dawley, female, weanling rats were divided into groups and fed 20% brussels sprouts diets containing either 0.03, 0.58, 1.29, or 6.71 ppm of selenium naturally occurring in the sprouts. These diets were fed 2 weeks before and 2 weeks after a single dose of 7,12-dimethylbenz[a]anthracene (DMBA), and the rats were then placed on a low selenium basal diet for an additional 25 weeks. All brussels sprouts diets reduced the incidence of DMBA-induced mammary carcinogenesis. Increased dietary levels of naturally occurring selenium did not further depress mammary tumorigenesis. The time period of selenium feeding may have been too brief to observe any additional tumor reductions.

Original languageEnglish (US)
Pages (from-to)43-48
Number of pages6
JournalCancer Letters
Volume45
Issue number1
DOIs
StatePublished - 1989
Externally publishedYes

Keywords

  • 7,12-dimethylbenz[a]anthracene
  • brussels sprouts
  • mammary cancer
  • rats
  • selenium

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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