Effect of diabetic retinopathy and panretinal photocoagulation on retinal nerve fiber layer and optic nerve appearance

Michele C Lim, Suzana A. Tanimoto, Bruno A. Furlani, Brent Lum, Luciano M. Pinto, David Eliason, Tiago S. Prata, James D Brandt, Lawrence S Morse, Susanna Soon Chun Park, Luiz A S Melo

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Objective: To determine if panretinal photocoagulation (PRP) alters retinal nerve fiber layer (RNFL) thickness and optic nerve appearance. Methods: Patients with diabetes who did and did not undergo PRP and nondiabetic control subjects were enrolled in a prospective study. Participants underwent optical coherence tomography of the peripapillary retina and optic nerve. Stereoscopic optic nerve photographs were graded in a masked fashion. Results: Ninety-four eyes of 48 healthy individuals, 89 eyes of 55 diabetic patients who did not undergo PRP, and 37 eyes of 24 subjects with diabetes who underwent PRP were included in this study. Eyes that had been treated with PRP had thinner peripapillary RNFL compared with the other groups; this was statistically significantly different in the inferior (P=.004) and nasal (P=.003) regions. Optic nerve cupping did not increase with severity of disease classification, but the proportion of optic nerves graded as suspicious for glaucoma or as having nonglaucomatous optic neuropathy did (P=.008). These grading categories were associated with thinner RNFL measurements. Conclusions: Diabetic eyes that have been treated with PRP have thinner RNFL than nondiabetic eyes. Optic nerves in eyes treated with PRP are more likely to be graded as abnormal, but their appearance is not necessarily glaucomatous and may be related to thinning of the RNFL.

Original languageEnglish (US)
Pages (from-to)857-862
Number of pages6
JournalArchives of Ophthalmology
Volume127
Issue number7
DOIs
StatePublished - Jul 2009

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ASJC Scopus subject areas

  • Ophthalmology

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