Effect of dexmedetomidine on the minimum infusion rate of propofol preventing movement in dogs

Christopher K. Smith, Reza Seddighi, Sherry K. Cox, Xiaocun Sun, Heather K Knych, Thomas J. Doherty

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Objective To determine the effect of dexmedetomidine on induction dose and minimum infusion rate of propofol preventing movement (MIRNM). Study design Randomized crossover, unmasked, experimental design. Animals Three male and three female healthy Beagle dogs weighing 10.2 ± 2.8 kg. Methods Dogs were studied on three occasions at weekly intervals. Premedications were 0.9% saline (treatment P) or dexmedetomidine (1 μg kg−1, treatment PLD; 2 μg kg−1, treatment PHD) intravenously. Anesthesia was induced with propofol (2 mg kg−1 and then 1 mg kg−1 every 15 seconds) until intubation. Anesthesia was maintained for 90 minutes in P with propofol (0.5 mg kg−1 minute−1) and saline, in PLD with propofol (0.35 mg kg−1 minute−1) and dexmedetomidine (1 μg kg−1 hour−1), and in PHD with propofol (0.3 mg kg−1 minute−1) and dexmedetomidine (2 μg kg−1 hour−1). The stimulus (50 V, 50 Hz, 10 ms) was applied to the antebrachium, and propofol infusion was increased or decreased by 0.025 mg kg−1 minute−1 based on a positive or negative response, respectively. Data were analyzed using a mixed-model ANOVA and presented as mean ± standard error. Results Propofol induction doses were 8.68 ± 0.57 (P), 6.13 ± 0.67 (PLD) and 4.78 ± 0.39 (PHD) mg kg−1 and differed among treatments (p < 0.05). Propofol MIRNM values were 0.68 ± 0.13, 0.49 ± 0.16 and 0.26 ± 0.05 mg kg−1 minute−1 for P, PLD and PHD, respectively. Propofol MIRNM decreased 59% in PHD (p < 0.05). Plasma propofol concentrations were 14.04 ± 2.30 (P), 11.30 ± 4.30 (PLD) and 7.96 ± 0.72 (PHD) μg mL−1 and dexmedetomidine concentrations were 0.68 ± 0.12 (PLD) and 0.89 ± 0.08 (PHD) ng mL−1 at MIRNM determination. Conclusions and clinical relevance Dexmedetomidine (1 and 2 μg kg−1) decreased propofol induction dose. Dexmedetomidine (2 μg kg−1 hour−1) resulted in a significant decrease in propofol MIRNM.

Original languageEnglish (US)
Pages (from-to)1287-1295
Number of pages9
JournalVeterinary Anaesthesia and Analgesia
Volume44
Issue number6
DOIs
StatePublished - Nov 1 2017

Keywords

  • anesthesia
  • dexmedetomidine
  • dogs
  • minimum infusion rate
  • propofol

ASJC Scopus subject areas

  • veterinary(all)

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