Effect of coupled oscillations on microbubble behavior

John S. Allen, Dustin E. Kruse, Paul A. Dayton, Katherine W. Ferrara

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Ultrasound contrast agents are encapsulated microbubbles whose nonlinear acoustic scattering signatures have been the foundation of their use in diagnostic imaging. The coupled oscillations of microbubbles along their lines of center are investigated theoretically using radial equations in the monopole approximation and an energy balance, which is obtained for the system. Coupled microbubble pairs of different initial radii are investigated numerically relative to the normal modes for the linearized system. For microbubble pairs of different size bubbles driven below the mode of the smaller bubble and above the mode of the larger bubble, it is shown that oscillations of the smaller agent are affected substantially more by the coupling than those of the larger one. For separation distances of 10 and 500 microns, a difference of approximately 10 dB occurs in the second harmonic output of a 1.0-micron radius agent coupled with a 2.2-micron radius agent forced at 2.0 MHz and 0.3 MPa. The subharmonic spectral peak is shown to decrease approximately 19 dB for the coupling of 1.5- and 2.2-micron radius agents at 10- and 500-micron distances under the same acoustic forcing conditions. These coupling effects on the radiated pressure and its spectral power are highlighted for contrast agent imaging applications.

Original languageEnglish (US)
Pages (from-to)1678-1690
Number of pages13
JournalJournal of the Acoustical Society of America
Volume114
Issue number3
DOIs
StatePublished - Sep 1 2003

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oscillations
radii
bubbles
acoustic scattering
monopoles
Oscillation
signatures
harmonics
acoustics
output
approximation
Bubble
Acoustics
Spectrality
Imaging
energy

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Cite this

Allen, J. S., Kruse, D. E., Dayton, P. A., & Ferrara, K. W. (2003). Effect of coupled oscillations on microbubble behavior. Journal of the Acoustical Society of America, 114(3), 1678-1690. https://doi.org/10.1121/1.1600721

Effect of coupled oscillations on microbubble behavior. / Allen, John S.; Kruse, Dustin E.; Dayton, Paul A.; Ferrara, Katherine W.

In: Journal of the Acoustical Society of America, Vol. 114, No. 3, 01.09.2003, p. 1678-1690.

Research output: Contribution to journalArticle

Allen, JS, Kruse, DE, Dayton, PA & Ferrara, KW 2003, 'Effect of coupled oscillations on microbubble behavior', Journal of the Acoustical Society of America, vol. 114, no. 3, pp. 1678-1690. https://doi.org/10.1121/1.1600721
Allen, John S. ; Kruse, Dustin E. ; Dayton, Paul A. ; Ferrara, Katherine W. / Effect of coupled oscillations on microbubble behavior. In: Journal of the Acoustical Society of America. 2003 ; Vol. 114, No. 3. pp. 1678-1690.
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