Effect of copper deficiency on prenatal development and pregnancy outcome

Carl L Keen, Janet Y. Uriu-Hare, Susan N. Hawk, Margaret A. Jankowski, George P. Daston, Catherine L. Kwik-Uribe, Robert B. Rucker

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

Copper deficiency during embryonic and fetal development can result in numerous gross structural and biochemical abnormalities. Such a deficiency can arise through a variety of mechanisms, including low maternal dietary copper intake, disease-induced or drug-induced changes in maternal and conceptus copper metabolism, or both. These issues are discussed in this article along with the use of in vitro embryo culture models to study the mechanisms underlying copper deficiency-induced teratogenesis. Current data suggest that changes in free radical defense mechanisms, connective tissue metabolism, and energy production can all contribute to the dysmorphogenesis associated with developmental copper deficiency.

Original languageEnglish (US)
JournalAmerican Journal of Clinical Nutrition
Volume67
Issue number5 SUPPL.
StatePublished - 1998

Fingerprint

prenatal development
pregnancy outcome
Pregnancy Outcome
Copper
copper
conceptus
Embryonic and Fetal Development
Mothers
embryo culture
Teratogenesis
fetal development
defense mechanisms
connective tissues
embryogenesis
Connective Tissue
Energy Metabolism
Free Radicals
drugs
Embryonic Structures
metabolism

Keywords

  • Copper
  • Development
  • Embryo culture
  • Fetal development
  • Oxidative damage
  • Pregnancy
  • Superoxide dismutase

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Keen, C. L., Uriu-Hare, J. Y., Hawk, S. N., Jankowski, M. A., Daston, G. P., Kwik-Uribe, C. L., & Rucker, R. B. (1998). Effect of copper deficiency on prenatal development and pregnancy outcome. American Journal of Clinical Nutrition, 67(5 SUPPL.).

Effect of copper deficiency on prenatal development and pregnancy outcome. / Keen, Carl L; Uriu-Hare, Janet Y.; Hawk, Susan N.; Jankowski, Margaret A.; Daston, George P.; Kwik-Uribe, Catherine L.; Rucker, Robert B.

In: American Journal of Clinical Nutrition, Vol. 67, No. 5 SUPPL., 1998.

Research output: Contribution to journalArticle

Keen, CL, Uriu-Hare, JY, Hawk, SN, Jankowski, MA, Daston, GP, Kwik-Uribe, CL & Rucker, RB 1998, 'Effect of copper deficiency on prenatal development and pregnancy outcome', American Journal of Clinical Nutrition, vol. 67, no. 5 SUPPL..
Keen CL, Uriu-Hare JY, Hawk SN, Jankowski MA, Daston GP, Kwik-Uribe CL et al. Effect of copper deficiency on prenatal development and pregnancy outcome. American Journal of Clinical Nutrition. 1998;67(5 SUPPL.).
Keen, Carl L ; Uriu-Hare, Janet Y. ; Hawk, Susan N. ; Jankowski, Margaret A. ; Daston, George P. ; Kwik-Uribe, Catherine L. ; Rucker, Robert B. / Effect of copper deficiency on prenatal development and pregnancy outcome. In: American Journal of Clinical Nutrition. 1998 ; Vol. 67, No. 5 SUPPL.
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