Effect of copper deficiency on prenatal development and pregnancy outcome

Carl L Keen, Janet Y. Uriu-Hare, Susan N. Hawk, Margaret A. Jankowski, George P. Daston, Catherine L. Kwik-Uribe, Robert B. Rucker

Research output: Contribution to journalArticlepeer-review

121 Scopus citations


Copper deficiency during embryonic and fetal development can result in numerous gross structural and biochemical abnormalities. Such a deficiency can arise through a variety of mechanisms, including low maternal dietary copper intake, disease-induced or drug-induced changes in maternal and conceptus copper metabolism, or both. These issues are discussed in this article along with the use of in vitro embryo culture models to study the mechanisms underlying copper deficiency-induced teratogenesis. Current data suggest that changes in free radical defense mechanisms, connective tissue metabolism, and energy production can all contribute to the dysmorphogenesis associated with developmental copper deficiency.

Original languageEnglish (US)
JournalAmerican Journal of Clinical Nutrition
Issue number5 SUPPL.
StatePublished - 1998


  • Copper
  • Development
  • Embryo culture
  • Fetal development
  • Oxidative damage
  • Pregnancy
  • Superoxide dismutase

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science


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