Abstract
The administration of concanavalin A (con A) to young New Zealand (NZB/W) mice has been found previously to render them tolerant to bovine γ globulin. The corresponding mechanism is unknown but is consistent with other observations that con A is capable of activating a suppressor T cell population. This possibility was further explored by giving New Zealand mice con A from 1 mth until 11 mth of age and monitoring several known immunologic abnormalities. Con A treated mice, in contrast to littermate controls, were found to have lower anti DNA levels, less proteinuria, a better response to primary sheep red cell immunization and normally rejected skin allografts.
Original language | English (US) |
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Pages (from-to) | 220-224 |
Number of pages | 5 |
Journal | International Archives of Allergy and Applied Immunology |
Volume | 48 |
Issue number | 2 |
State | Published - 1975 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy