Effect of concanavalin A on immunologic abnormalities of New Zealand (NZB/W) mice

M. Eric Gershwin, A. D. Steinberg

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The administration of concanavalin A (con A) to young New Zealand (NZB/W) mice has been found previously to render them tolerant to bovine γ globulin. The corresponding mechanism is unknown but is consistent with other observations that con A is capable of activating a suppressor T cell population. This possibility was further explored by giving New Zealand mice con A from 1 mth until 11 mth of age and monitoring several known immunologic abnormalities. Con A treated mice, in contrast to littermate controls, were found to have lower anti DNA levels, less proteinuria, a better response to primary sheep red cell immunization and normally rejected skin allografts.

Original languageEnglish (US)
Pages (from-to)220-224
Number of pages5
JournalInternational Archives of Allergy and Applied Immunology
Volume48
Issue number2
StatePublished - 1975
Externally publishedYes

Fingerprint

Inbred NZB Mouse
Concanavalin A
New Zealand
Globulins
Proteinuria
Allografts
Immunization
Sheep
T-Lymphocytes
Skin
DNA
Population

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Effect of concanavalin A on immunologic abnormalities of New Zealand (NZB/W) mice. / Gershwin, M. Eric; Steinberg, A. D.

In: International Archives of Allergy and Applied Immunology, Vol. 48, No. 2, 1975, p. 220-224.

Research output: Contribution to journalArticle

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