Abstract
The administration of concanavalin A (con A) to young New Zealand (NZB/W) mice has been found previously to render them tolerant to bovine γ globulin. The corresponding mechanism is unknown but is consistent with other observations that con A is capable of activating a suppressor T cell population. This possibility was further explored by giving New Zealand mice con A from 1 mth until 11 mth of age and monitoring several known immunologic abnormalities. Con A treated mice, in contrast to littermate controls, were found to have lower anti DNA levels, less proteinuria, a better response to primary sheep red cell immunization and normally rejected skin allografts.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 220-224 |
| Number of pages | 5 |
| Journal | International Archives of Allergy and Applied Immunology |
| Volume | 48 |
| Issue number | 2 |
| State | Published - 1975 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology and Allergy
Cite this
Effect of concanavalin A on immunologic abnormalities of New Zealand (NZB/W) mice. / Gershwin, M. Eric; Steinberg, A. D.
In: International Archives of Allergy and Applied Immunology, Vol. 48, No. 2, 1975, p. 220-224.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of concanavalin A on immunologic abnormalities of New Zealand (NZB/W) mice
AU - Gershwin, M. Eric
AU - Steinberg, A. D.
PY - 1975
Y1 - 1975
N2 - The administration of concanavalin A (con A) to young New Zealand (NZB/W) mice has been found previously to render them tolerant to bovine γ globulin. The corresponding mechanism is unknown but is consistent with other observations that con A is capable of activating a suppressor T cell population. This possibility was further explored by giving New Zealand mice con A from 1 mth until 11 mth of age and monitoring several known immunologic abnormalities. Con A treated mice, in contrast to littermate controls, were found to have lower anti DNA levels, less proteinuria, a better response to primary sheep red cell immunization and normally rejected skin allografts.
AB - The administration of concanavalin A (con A) to young New Zealand (NZB/W) mice has been found previously to render them tolerant to bovine γ globulin. The corresponding mechanism is unknown but is consistent with other observations that con A is capable of activating a suppressor T cell population. This possibility was further explored by giving New Zealand mice con A from 1 mth until 11 mth of age and monitoring several known immunologic abnormalities. Con A treated mice, in contrast to littermate controls, were found to have lower anti DNA levels, less proteinuria, a better response to primary sheep red cell immunization and normally rejected skin allografts.
UR - http://www.scopus.com/inward/record.url?scp=0016439223&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016439223&partnerID=8YFLogxK
M3 - Article
VL - 48
SP - 220
EP - 224
JO - International Archives of Allergy and Immunology
JF - International Archives of Allergy and Immunology
SN - 1018-2438
IS - 2
ER -