NZB/W mice 4 wk old or more are not easily made tolerant by the ultracentrifuged protein antigen BGG. Younger mice can be made tolerant, but they escape rapidly. Recent studies suggest a loss of regulatory or suppressor cells in the pathogenesis of immunologic abnormalities early in life in NZB/W mice. Several reports indicate that Concanavalin A (Con A) is capable of activating suppressor cells in normal mice. It was found that Con A could prolong the period of tolerance in NZB/W mice when ultracentrifuged BCG was given at 20 days of age. NZB/W mice given ultracentrifuged BCG at 4 wk of age were not tolerant to subsequent challenge with BGG in adjuvant unless they also received Con A. These studies are compatable with the hypothesis that Con A activates suppressor cell activity which is deficient in NZB/W mice. Alternative explanations of these phenomena are discussed.
|Original language||English (US)|
|Number of pages||5|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - 1974|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)