Abstract
The effect of clindamycin on growth and haemolysin production by four strains of Escherichia coli was tested. Clindamycin MICs were > 256 mg/l for all strains. Clindamycin concentrations of 16-256 mg/l significantly inhibited growth, while concentrations from 2-32 mg/l significantly inhibited haemolysin production. Administration of clindamycin to rats with peritonitis due to haemolytic E. coli reduced mortality. Subinhibitory concentrations of clindamycin can inhibit growth and haemolysin production by E. coli and reduce mortality in an animal model of haemolytic E. coli peritonitis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 105-116 |
| Number of pages | 12 |
| Journal | Journal of Antimicrobial Chemotherapy |
| Volume | 12 |
| Issue number | SUPPL. C |
| State | Published - 1983 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Microbiology
- Pharmacology
Cite this
Effect of clindamycin on growth and haemolysin production by Escherichia coli. / Boe, Nina; Patchen Dellinger, E.; Minshew, B. H.
In: Journal of Antimicrobial Chemotherapy, Vol. 12, No. SUPPL. C, 1983, p. 105-116.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of clindamycin on growth and haemolysin production by Escherichia coli
AU - Boe, Nina
AU - Patchen Dellinger, E.
AU - Minshew, B. H.
PY - 1983
Y1 - 1983
N2 - The effect of clindamycin on growth and haemolysin production by four strains of Escherichia coli was tested. Clindamycin MICs were > 256 mg/l for all strains. Clindamycin concentrations of 16-256 mg/l significantly inhibited growth, while concentrations from 2-32 mg/l significantly inhibited haemolysin production. Administration of clindamycin to rats with peritonitis due to haemolytic E. coli reduced mortality. Subinhibitory concentrations of clindamycin can inhibit growth and haemolysin production by E. coli and reduce mortality in an animal model of haemolytic E. coli peritonitis.
AB - The effect of clindamycin on growth and haemolysin production by four strains of Escherichia coli was tested. Clindamycin MICs were > 256 mg/l for all strains. Clindamycin concentrations of 16-256 mg/l significantly inhibited growth, while concentrations from 2-32 mg/l significantly inhibited haemolysin production. Administration of clindamycin to rats with peritonitis due to haemolytic E. coli reduced mortality. Subinhibitory concentrations of clindamycin can inhibit growth and haemolysin production by E. coli and reduce mortality in an animal model of haemolytic E. coli peritonitis.
UR - http://www.scopus.com/inward/record.url?scp=0021079859&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021079859&partnerID=8YFLogxK
M3 - Article
C2 - 6358179
AN - SCOPUS:0021079859
VL - 12
SP - 105
EP - 116
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
SN - 0305-7453
IS - SUPPL. C
ER -