Effect of chronic renal failure and growth hormone therapy on the insulin-like growth factors and their binding proteins

David R. Powell, Frances Liu, Bonita K. Baker, Raymond L. Hintz, Arundhati S Kale, Adisak Suwanichkul, Susan K. Durham

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Children with chronic renal failure (CRF) are often growth retarded, and abnormalities of the growth hormone (GH)/insulin-like growth factor (IGF) axis in CRF may contribute to this poor growth. Despite normal IGF levels in CRF serum, IGF bioactivity is low due to excess IGF-binding proteins (IGFBPs) in the 35-kDa serum fractions. Levels of IGFBP-1, -2, -4 and -6, and a 29-kDa IGFBP-3 fragment, are high in CRF serum, and levels of intact IGFBP-1 and -2 correlate negatively with height. IGFBP-1 levels may be high due to insulin resistance, suggesting that the FKHR family of transcription factors may play a role in the overexpression of IGFBP-1, and other growth inhibitors, in CRF. GH-treated CRF children show catch-up growth that correlates positively with a rise in each component of the 150-kDa serum ternary complex (IGF-I or -II/IGFBP-3 or -5/acid-labile subunit); IGFBP-1, -2 and -6 levels do not rise, but serum IGF bioactivity does. Thus, GH increases levels of IGFs and ternary complexes in CRF serum. It is likely that increased IGFs contribute to catch-up growth by overcoming the inhibitory effects of excess IGFBPs present in the CRF milieu.

Original languageEnglish (US)
Pages (from-to)579-583
Number of pages5
JournalPediatric Nephrology
Volume14
Issue number7
StatePublished - Jul 1 2000
Externally publishedYes

Keywords

  • Growth
  • Growth hormone
  • Insulin-like growth factor
  • Uremia

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

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    Powell, D. R., Liu, F., Baker, B. K., Hintz, R. L., Kale, A. S., Suwanichkul, A., & Durham, S. K. (2000). Effect of chronic renal failure and growth hormone therapy on the insulin-like growth factors and their binding proteins. Pediatric Nephrology, 14(7), 579-583.