Abstract
Morphine addiction was induced in six male Wistar rats. Improved glucose tolerance (peak value less by 28%, p < 0.01) was observed in chronically morphinized rats as compared to the control rats, injected with saline. An increase in the maximal specific binding of 125I-labeled insulin to unit membrane area of adipocytes was observed in the experimental group (p < 0.01). The changes in insulin receptor number could be responsible for the improved glucose tolerance observed during morphine addiction.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 215-221 |
| Number of pages | 7 |
| Journal | Endocrine Research |
| Volume | 27 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Jul 4 2001 |
| Externally published | Yes |
ASJC Scopus subject areas
- Endocrinology
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Sood, A., Thakur, V. S., Karmarkar, M. G., & Ahuja, M. M. S. (2001). Effect of chronic morphine administration on glucose tolerance and insulin binding to isolated rat adipocytes. Endocrine Research, 27(1-2), 215-221. https://doi.org/10.1081/ERC-100107182