Effect of chronic morphine administration on glucose tolerance and insulin binding to isolated rat adipocytes

Ajay Sood; V. S. Thakur; M. G. Karmarkar; M. M.S. Ahuja

doi:10.1081/ERC-100107182

Effect of chronic morphine administration on glucose tolerance and insulin binding to isolated rat adipocytes

Ajay Sood, V. S. Thakur, M. G. Karmarkar, M. M.S. Ahuja

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Morphine addiction was induced in six male Wistar rats. Improved glucose tolerance (peak value less by 28%, p < 0.01) was observed in chronically morphinized rats as compared to the control rats, injected with saline. An increase in the maximal specific binding of ¹²⁵I-labeled insulin to unit membrane area of adipocytes was observed in the experimental group (p < 0.01). The changes in insulin receptor number could be responsible for the improved glucose tolerance observed during morphine addiction.

Original language	English (US)
Pages (from-to)	215-221
Number of pages	7
Journal	Endocrine Research
Volume	27
Issue number	1-2
DOIs	https://doi.org/10.1081/ERC-100107182
State	Published - Jul 4 2001
Externally published	Yes

ASJC Scopus subject areas

Endocrinology

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AU - Thakur, V. S.

AU - Karmarkar, M. G.

AU - Ahuja, M. M.S.

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AB - Morphine addiction was induced in six male Wistar rats. Improved glucose tolerance (peak value less by 28%, p < 0.01) was observed in chronically morphinized rats as compared to the control rats, injected with saline. An increase in the maximal specific binding of 125I-labeled insulin to unit membrane area of adipocytes was observed in the experimental group (p < 0.01). The changes in insulin receptor number could be responsible for the improved glucose tolerance observed during morphine addiction.

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Effect of chronic morphine administration on glucose tolerance and insulin binding to isolated rat adipocytes

Abstract

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