Effect of chronic morphine administration on glucose tolerance and insulin binding to isolated rat adipocytes

Ajay Sood, V. S. Thakur, M. G. Karmarkar, M. M.S. Ahuja

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Morphine addiction was induced in six male Wistar rats. Improved glucose tolerance (peak value less by 28%, p < 0.01) was observed in chronically morphinized rats as compared to the control rats, injected with saline. An increase in the maximal specific binding of 125I-labeled insulin to unit membrane area of adipocytes was observed in the experimental group (p < 0.01). The changes in insulin receptor number could be responsible for the improved glucose tolerance observed during morphine addiction.

Original languageEnglish (US)
Pages (from-to)215-221
Number of pages7
JournalEndocrine Research
Volume27
Issue number1-2
DOIs
StatePublished - Jul 4 2001
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology

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