Abstract
Morphine addiction was induced in six male Wistar rats. Improved glucose tolerance (peak value less by 28%, p < 0.01) was observed in chronically morphinized rats as compared to the control rats, injected with saline. An increase in the maximal specific binding of 125I-labeled insulin to unit membrane area of adipocytes was observed in the experimental group (p < 0.01). The changes in insulin receptor number could be responsible for the improved glucose tolerance observed during morphine addiction.
Original language | English (US) |
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Pages (from-to) | 215-221 |
Number of pages | 7 |
Journal | Endocrine Research |
Volume | 27 |
Issue number | 1-2 |
DOIs | |
State | Published - Jul 4 2001 |
Externally published | Yes |
ASJC Scopus subject areas
- Endocrinology