Effect of changing polymer chain length on the target-mediated agglutination of polymer-grafted nanoparticles

Philip J. Costanzo, Nily Dan, Katherine S. Lancaster, Carlito B Lebrilla, Timothy E. Patten

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The preparation and agglutination of poly(ethylene glycol) (PEG) grafted SiO2 nanoparticles with biotin chain ends were studied to investigate the effect of varying molecular weight of the PEG chain on the behavior of the system. Nuclear magnetic resonance (NMR) spectrum studies of polymer show that the signal due to the methylene unit adjacent to the azido chain end overlaps with the backbone methylene signals. The avidin concentration is found to be proportional to the number of biotin chains in the system and is found that the larger the number of functionalized chains per particle, the higher the number of avidin molecules required to induce aggregation. The end-grafted polymer layers are found to possess uniform chain stretching, where all chain ends are located at the outer brush edge.

Original languageEnglish (US)
Pages (from-to)1570-1576
Number of pages7
JournalMacromolecules
Volume41
Issue number4
DOIs
StatePublished - Feb 26 2008

Fingerprint

Chain length
Polyethylene glycols
Polymers
Avidin
Biotin
Nanoparticles
Brushes
Stretching
Agglomeration
Molecular weight
Nuclear magnetic resonance
Molecules

ASJC Scopus subject areas

  • Materials Chemistry

Cite this

Costanzo, P. J., Dan, N., Lancaster, K. S., Lebrilla, C. B., & Patten, T. E. (2008). Effect of changing polymer chain length on the target-mediated agglutination of polymer-grafted nanoparticles. Macromolecules, 41(4), 1570-1576. https://doi.org/10.1021/ma7021343

Effect of changing polymer chain length on the target-mediated agglutination of polymer-grafted nanoparticles. / Costanzo, Philip J.; Dan, Nily; Lancaster, Katherine S.; Lebrilla, Carlito B; Patten, Timothy E.

In: Macromolecules, Vol. 41, No. 4, 26.02.2008, p. 1570-1576.

Research output: Contribution to journalArticle

Costanzo, PJ, Dan, N, Lancaster, KS, Lebrilla, CB & Patten, TE 2008, 'Effect of changing polymer chain length on the target-mediated agglutination of polymer-grafted nanoparticles', Macromolecules, vol. 41, no. 4, pp. 1570-1576. https://doi.org/10.1021/ma7021343
Costanzo, Philip J. ; Dan, Nily ; Lancaster, Katherine S. ; Lebrilla, Carlito B ; Patten, Timothy E. / Effect of changing polymer chain length on the target-mediated agglutination of polymer-grafted nanoparticles. In: Macromolecules. 2008 ; Vol. 41, No. 4. pp. 1570-1576.
@article{1fb6f5aa0eda4d7da3ec6fa8b6e51613,
title = "Effect of changing polymer chain length on the target-mediated agglutination of polymer-grafted nanoparticles",
abstract = "The preparation and agglutination of poly(ethylene glycol) (PEG) grafted SiO2 nanoparticles with biotin chain ends were studied to investigate the effect of varying molecular weight of the PEG chain on the behavior of the system. Nuclear magnetic resonance (NMR) spectrum studies of polymer show that the signal due to the methylene unit adjacent to the azido chain end overlaps with the backbone methylene signals. The avidin concentration is found to be proportional to the number of biotin chains in the system and is found that the larger the number of functionalized chains per particle, the higher the number of avidin molecules required to induce aggregation. The end-grafted polymer layers are found to possess uniform chain stretching, where all chain ends are located at the outer brush edge.",
author = "Costanzo, {Philip J.} and Nily Dan and Lancaster, {Katherine S.} and Lebrilla, {Carlito B} and Patten, {Timothy E.}",
year = "2008",
month = "2",
day = "26",
doi = "10.1021/ma7021343",
language = "English (US)",
volume = "41",
pages = "1570--1576",
journal = "Macromolecules",
issn = "0024-9297",
publisher = "American Chemical Society",
number = "4",

}

TY - JOUR

T1 - Effect of changing polymer chain length on the target-mediated agglutination of polymer-grafted nanoparticles

AU - Costanzo, Philip J.

AU - Dan, Nily

AU - Lancaster, Katherine S.

AU - Lebrilla, Carlito B

AU - Patten, Timothy E.

PY - 2008/2/26

Y1 - 2008/2/26

N2 - The preparation and agglutination of poly(ethylene glycol) (PEG) grafted SiO2 nanoparticles with biotin chain ends were studied to investigate the effect of varying molecular weight of the PEG chain on the behavior of the system. Nuclear magnetic resonance (NMR) spectrum studies of polymer show that the signal due to the methylene unit adjacent to the azido chain end overlaps with the backbone methylene signals. The avidin concentration is found to be proportional to the number of biotin chains in the system and is found that the larger the number of functionalized chains per particle, the higher the number of avidin molecules required to induce aggregation. The end-grafted polymer layers are found to possess uniform chain stretching, where all chain ends are located at the outer brush edge.

AB - The preparation and agglutination of poly(ethylene glycol) (PEG) grafted SiO2 nanoparticles with biotin chain ends were studied to investigate the effect of varying molecular weight of the PEG chain on the behavior of the system. Nuclear magnetic resonance (NMR) spectrum studies of polymer show that the signal due to the methylene unit adjacent to the azido chain end overlaps with the backbone methylene signals. The avidin concentration is found to be proportional to the number of biotin chains in the system and is found that the larger the number of functionalized chains per particle, the higher the number of avidin molecules required to induce aggregation. The end-grafted polymer layers are found to possess uniform chain stretching, where all chain ends are located at the outer brush edge.

UR - http://www.scopus.com/inward/record.url?scp=40549094019&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40549094019&partnerID=8YFLogxK

U2 - 10.1021/ma7021343

DO - 10.1021/ma7021343

M3 - Article

AN - SCOPUS:40549094019

VL - 41

SP - 1570

EP - 1576

JO - Macromolecules

JF - Macromolecules

SN - 0024-9297

IS - 4

ER -