Effect of cerium oxide nanoparticles on inflammation in vascular endothelial cells

Andrea Gojova, Jun Tae Lee, Heejung S. Jung, Bing Guo, Abdul I. Barakat, Ian M. Kennedy

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

Because vascular endothelial cell inflammation is critical in the development of cardiovascular pathology, we hypothesized that direct exposure of human aortic endothelial cells (HAECs) to ultrafine particles induces an inflammatory response. To test the hypothesis, we incubated HAECs for 4h with different concentrations (0.00150μg/ml) of CeO2 nanoparticles and subsequently measured mRNA levels of the three inflammatory markers intercellular adhesion molecule 1 (ICAM-1), interleukin (IL)-8, and monocyte chemotactic protein (MCP-1) using real-time polymerase chain reaction (PCR). Ceria nanoparticles caused very little inflammatory response in HAECs, even at the highest dose. This material is apparently rather benign in comparison with Y2O3 and ZnO nanoparticles that we have studied previously. These results suggest that inflammation in HAECs following acute exposure to metal oxide nanoparticles depends strongly on particle composition.

Original languageEnglish (US)
Pages (from-to)123-130
Number of pages8
JournalInhalation Toxicology
Volume21
Issue numberSUPPL. 1
DOIs
StatePublished - 2009

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Keywords

  • Ceria
  • Endothelial
  • Inflammation
  • Nanoparticles

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Gojova, A., Lee, J. T., Jung, H. S., Guo, B., Barakat, A. I., & Kennedy, I. M. (2009). Effect of cerium oxide nanoparticles on inflammation in vascular endothelial cells. Inhalation Toxicology, 21(SUPPL. 1), 123-130. https://doi.org/10.1080/08958370902942582