Effect of cadmium ion on respiration and ATPase activity of the pulmonary alveolar macrophage: A model for the study of environmental interference with pulmonary cell function

Carroll E Cross, A. B. Ibrahim, M. Ahmed, M. G. Mustafa

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Abstract

A study was made on the effect of Cd2+ on respiration and adenosinetriphosphatase activity of pulmonary alveolar macrophage (PAM) cells. Approximately 5 mm Cd2+ inhibited endogenous respiration in PAM cells and 0.5 mm Cd2+ inhibited respiration in mitochondria of PAM cells. Tetramethyl-p-phenylenediamine, an artificial electron carrier, restored the Cd2+-inhibited respiration in both cells and mitochondria, indicating that Cd2+ presumably bound certain respiratory chain components. Cadmium ion also inhibited the Na+K+, Mg2+ ATPase system of PAM cells and cellular membranes. The interaction of this metal ion with the vital processes of respiration and energy transfer in PAM cells might relate to pulmonary pathology arising from occupational and environmental exposure to cadmium. It is hypothesized that the biochemical alterations of pulmonary cells may be more sensitive and easily discernible parameters of the manifestations of noxious inhalants than the conventional pathophysiological parameters.

Original languageEnglish (US)
Pages (from-to)512-520
Number of pages9
JournalEnvironmental Research
Volume3
Issue number5-6
DOIs
StatePublished - 1970

Fingerprint

Alveolar Macrophages
Cadmium
Adenosine Triphosphatases
Respiration
respiration
cadmium
Ions
Alveolar Epithelial Cells
Lung
ion
Mitochondria
mitochondrion
Ca(2+) Mg(2+)-ATPase
Pathology
pathology
Energy transfer
Metal ions
effect
membrane
Membranes

ASJC Scopus subject areas

  • Environmental Science(all)

Cite this

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abstract = "A study was made on the effect of Cd2+ on respiration and adenosinetriphosphatase activity of pulmonary alveolar macrophage (PAM) cells. Approximately 5 mm Cd2+ inhibited endogenous respiration in PAM cells and 0.5 mm Cd2+ inhibited respiration in mitochondria of PAM cells. Tetramethyl-p-phenylenediamine, an artificial electron carrier, restored the Cd2+-inhibited respiration in both cells and mitochondria, indicating that Cd2+ presumably bound certain respiratory chain components. Cadmium ion also inhibited the Na+K+, Mg2+ ATPase system of PAM cells and cellular membranes. The interaction of this metal ion with the vital processes of respiration and energy transfer in PAM cells might relate to pulmonary pathology arising from occupational and environmental exposure to cadmium. It is hypothesized that the biochemical alterations of pulmonary cells may be more sensitive and easily discernible parameters of the manifestations of noxious inhalants than the conventional pathophysiological parameters.",
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AU - Cross, Carroll E

AU - Ibrahim, A. B.

AU - Ahmed, M.

AU - Mustafa, M. G.

PY - 1970

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N2 - A study was made on the effect of Cd2+ on respiration and adenosinetriphosphatase activity of pulmonary alveolar macrophage (PAM) cells. Approximately 5 mm Cd2+ inhibited endogenous respiration in PAM cells and 0.5 mm Cd2+ inhibited respiration in mitochondria of PAM cells. Tetramethyl-p-phenylenediamine, an artificial electron carrier, restored the Cd2+-inhibited respiration in both cells and mitochondria, indicating that Cd2+ presumably bound certain respiratory chain components. Cadmium ion also inhibited the Na+K+, Mg2+ ATPase system of PAM cells and cellular membranes. The interaction of this metal ion with the vital processes of respiration and energy transfer in PAM cells might relate to pulmonary pathology arising from occupational and environmental exposure to cadmium. It is hypothesized that the biochemical alterations of pulmonary cells may be more sensitive and easily discernible parameters of the manifestations of noxious inhalants than the conventional pathophysiological parameters.

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