Effect of butylated hydroxytoluene and other antioxidants on mouse lung metabolism

S. T. Omaye, K. A. Reddy, Carroll E Cross

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Toxic doses of butylated hydroxytoluene (BHT), a phenolic antioxidant commonly used as a food additive, are known to produce lung damage. In this study, 3 days after a single ip injection of 62.5, 215, or 500 mg/kg BHT in mice there was a dose-dependent increase in lung weight. This concentration dependence with injected BHT was accompanied by increases in lung DNA and nonprotein sulfhydryl levels and in whole lung tissue enzyme activities of glutathione (GSH) peroxidase, GSH reductase, glucose-6-phosphate dehydrogenase, and superoxide dismutase. The increased enzyme activities are considered to correspond to inflammatory and proliferative pulmonary changes from acute lung cell injury and necrosis, which have been described previously, and cannot be construed as evidence for a primary oxidant-induced pulmonary lesion. The mechanism of BHT-induced lung changes may not be related to the antioxidant property of BHT, since vitamin E, n-propyl gallate, ethoxyquin, N,N'-diphenylenediamine, and the structurally similar compound, butylated hydroxyanisole did not appear to produce the gross anatomical or biochemical lung changes observed with BHT.

Original languageEnglish (US)
Pages (from-to)829-836
Number of pages8
JournalJournal of Toxicology and Environmental Health
Volume3
Issue number5-6
StatePublished - 1977

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Butylated Hydroxytoluene
Enzyme activity
Antioxidants
Metabolism
Butylated hydroxyanisole
Food additives
Lung
Vitamins
Oxidants
Glucose
Phosphates
DNA
Tissue
Ethoxyquin
Propyl Gallate
Butylated Hydroxyanisole
Glucosephosphate Dehydrogenase
Poisons
Vitamin E
Food Additives

ASJC Scopus subject areas

  • Toxicology
  • Pollution

Cite this

Effect of butylated hydroxytoluene and other antioxidants on mouse lung metabolism. / Omaye, S. T.; Reddy, K. A.; Cross, Carroll E.

In: Journal of Toxicology and Environmental Health, Vol. 3, No. 5-6, 1977, p. 829-836.

Research output: Contribution to journalArticle

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