Effect of bovine respiratory syncytial virus infection on hypersensitivity to inhaled Micropolyspora faeni

L. J. Gershwin, S. R. Himes, D. L. Dungworth, S. N. Giri, K. E. Friebertshauser, M. Camacho

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Respiratory syncytial virus causes mild-to-severe respiratory disease in human infants and young children; a closely related bovine respiratory syncytial virus causes a similar disease pattern in calves. Increased disease severity in atopic children suggests that allergic reactivity may enhance the severity of RSV-induced disease. To examine the association between bovine respiratory syncytial virus (BRSV) infection and allergic reactivity two groups of calves were exposed to aerosolized Micropolyspora faeni (Mf) during an experimental BRSV infection. One group exposed to Mf concurrent with BRSV was challenge-exposed to Mf while infected a second time with BRSV, while the other similarly sensitized and infected group was mock challenged. A control group was exposed only to Mf aerosol and another control group was infected with virus but not exposed to Mf aerosol. Parameters examined included: clinical signs, Mf-specific IgG and IgE, BRSV-specific antibody and IgE, leukotrienes C4 and B4 prostaglandins E2, F(2α) and D2, and lung pathology. While the initial BRSV infection failed to enhance sensitization to inhaled Mf, a second BRSV infection excerbated cinical signs resulting from Mf aerosol. Consideration of eicosanoid and antibody profiles together with clinical signs suggests that mechanisms of both type I and type III hypersensitivity were operative during Mf challenge of sensitized calves.

Original languageEnglish (US)
Pages (from-to)79-91
Number of pages13
JournalInternational Archives of Allergy and Immunology
Volume104
Issue number1
StatePublished - 1994
Externally publishedYes

Keywords

  • Bovine respiratory syncytial virus
  • Calves
  • Eicosanoid
  • Hypersensitivity
  • IgE
  • Micropolyspora faeni

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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