Effect of biliary obstruction on the hepatic excretion of imipenem- cilastatin

Joseph Leung, C. Y. Chan, C. W. Lai, T. C. Ko, A. F B Cheng, G. L. French

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

The biliary excretion of imipenem-cilastatin studied by endoscopic cannulation of the common bile duct in patients with complete obstruction and in a group without obstruction showed that despite a 24-h prophylaxis, the bile obtained from patients with obstruction immediately after cannulation contained neither imipenem nor cilastatin, while there were 2 and 5% of peak concentrations in serum for imipenem and cilastatin, respectively, in the bile from patients without obstruction. Biliary excretion of both compounds increased rapidly after decompression, reaching a maximum of 15% of peak levels in serum within 2 h. Twenty-four hours after drainage, the biliary excretion of the drugs further improved. We conclude that since biliary obstruction impairs excretion of antibiotics, drainage is necessary for the control of sepsis in obstructed cholangitis.

Original languageEnglish (US)
Pages (from-to)2057-2060
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume36
Issue number9
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology (medical)

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    Leung, J., Chan, C. Y., Lai, C. W., Ko, T. C., Cheng, A. F. B., & French, G. L. (1992). Effect of biliary obstruction on the hepatic excretion of imipenem- cilastatin. Antimicrobial Agents and Chemotherapy, 36(9), 2057-2060.