Effect of arterial occlusion on responses of group III and IV afferents to dynamic exercise

Christine M. Adreani, Marc P Kaufman

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Our laboratory has shown previously that a low level of dynamic exercise induced by electrical stimulation of the mesencephalic locomotor region (MLR) stimulated group III and IV muscle afferents in decerebrate unanesthetized cats (C. M. Adreani, J. M. Hill, and M.P. Kaufman. J. Appl. Physiol. 83: 1811-1817, 1997). In the present study, we have extended these findings by examining the effect of occluding the arterial supply to the dynamically exercising muscles on the afferents' responses to MLR stimulation. In decerebrate cats, we found that arterial occlusion increased the responsiveness to a low level of dynamic exercise in 44% of the group III and 47% of the group IV afferents tested. Occlusion, compared with the freely perfused state, did not increase the concentrations of either hydrogen ion or lactate ion in the venous effluent from the exercising muscles. We conclude that arterial occlusion caused some unspecified substance to accumulate in the working muscles to increase the sensitivity of equal percentages of group III and IV afferents to dynamic exercise.

Original languageEnglish (US)
Pages (from-to)1827-1833
Number of pages7
JournalJournal of Applied Physiology
Volume84
Issue number6
StatePublished - Jun 1998

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Muscles
Cats
Electric Stimulation
Lactic Acid
Ions

Keywords

  • Decerebrate cats
  • Ischemia
  • Muscular contraction
  • Sensory nerves

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Effect of arterial occlusion on responses of group III and IV afferents to dynamic exercise. / Adreani, Christine M.; Kaufman, Marc P.

In: Journal of Applied Physiology, Vol. 84, No. 6, 06.1998, p. 1827-1833.

Research output: Contribution to journalArticle

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