Effect of alveolar volume and sequential filling on the diffusing capacity of the lungs: II. Experiment

Nikolaos M. Tsoukias, Donald Dabdub, Archie F. Wilson, Steven George

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The diffusing capacity of the lung, DL, is a critical physiological parameter, yet the currently accepted clinical model (Jones-Meade) assumes a well-mixed alveolar region, and a constant DL independent of alveolar volume, VA, despite experimental evidence to the contrary. We have formulated a new mathematical model [Tsoukias, N.M, Wilson, A.F., George, S.C., 2000. Respir. Physiol. 120, 231-249] that considers variable alveolar mixing through a single parameter, k (0<k<1), and a DL that is a positive function of VA (DL=a+bVA or DL=αVA(β)). The goal of this study is to determine the suitability of this model to determine the unknown parameters a, b, α, β, and k from experimental data in normal subjects. The model predicts that the normal lung fills, in part, sequentially (k=0.51±0.35). The following average values in all seven subjects were obtained: DLNO=48.VA(2/3) ml/min/mmHg and DLCO=20+0.7.VA ml/min/mmHg (STPD) where VA is expressed in L (STPD). We conclude that the mathematical model is suitable for identifying the unknown parameters and thus can be used to characterize the degree of alveolar mixing (or sequential filling) as well as the volume dependence of DL. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)251-271
Number of pages21
JournalRespiration Physiology
Volume120
Issue number3
DOIs
StatePublished - May 1 2000

Fingerprint

Lung Volume Measurements
Theoretical Models
Lung
M 92

Keywords

  • Carbon monoxide, lung diffusing capacity
  • Gas exchange, diffusing capacity
  • Mammals, humans
  • Mediators, NO

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

Cite this

Effect of alveolar volume and sequential filling on the diffusing capacity of the lungs : II. Experiment. / Tsoukias, Nikolaos M.; Dabdub, Donald; Wilson, Archie F.; George, Steven.

In: Respiration Physiology, Vol. 120, No. 3, 01.05.2000, p. 251-271.

Research output: Contribution to journalArticle

Tsoukias, Nikolaos M. ; Dabdub, Donald ; Wilson, Archie F. ; George, Steven. / Effect of alveolar volume and sequential filling on the diffusing capacity of the lungs : II. Experiment. In: Respiration Physiology. 2000 ; Vol. 120, No. 3. pp. 251-271.
@article{2ba11081c58f4ffc87d834fad56d86d1,
title = "Effect of alveolar volume and sequential filling on the diffusing capacity of the lungs: II. Experiment",
abstract = "The diffusing capacity of the lung, DL, is a critical physiological parameter, yet the currently accepted clinical model (Jones-Meade) assumes a well-mixed alveolar region, and a constant DL independent of alveolar volume, VA, despite experimental evidence to the contrary. We have formulated a new mathematical model [Tsoukias, N.M, Wilson, A.F., George, S.C., 2000. Respir. Physiol. 120, 231-249] that considers variable alveolar mixing through a single parameter, k (0",
keywords = "Carbon monoxide, lung diffusing capacity, Gas exchange, diffusing capacity, Mammals, humans, Mediators, NO",
author = "Tsoukias, {Nikolaos M.} and Donald Dabdub and Wilson, {Archie F.} and Steven George",
year = "2000",
month = "5",
day = "1",
doi = "10.1016/S0034-5687(00)00104-3",
language = "English (US)",
volume = "120",
pages = "251--271",
journal = "Respiratory Physiology and Neurobiology",
issn = "1569-9048",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - Effect of alveolar volume and sequential filling on the diffusing capacity of the lungs

T2 - II. Experiment

AU - Tsoukias, Nikolaos M.

AU - Dabdub, Donald

AU - Wilson, Archie F.

AU - George, Steven

PY - 2000/5/1

Y1 - 2000/5/1

N2 - The diffusing capacity of the lung, DL, is a critical physiological parameter, yet the currently accepted clinical model (Jones-Meade) assumes a well-mixed alveolar region, and a constant DL independent of alveolar volume, VA, despite experimental evidence to the contrary. We have formulated a new mathematical model [Tsoukias, N.M, Wilson, A.F., George, S.C., 2000. Respir. Physiol. 120, 231-249] that considers variable alveolar mixing through a single parameter, k (0

AB - The diffusing capacity of the lung, DL, is a critical physiological parameter, yet the currently accepted clinical model (Jones-Meade) assumes a well-mixed alveolar region, and a constant DL independent of alveolar volume, VA, despite experimental evidence to the contrary. We have formulated a new mathematical model [Tsoukias, N.M, Wilson, A.F., George, S.C., 2000. Respir. Physiol. 120, 231-249] that considers variable alveolar mixing through a single parameter, k (0

KW - Carbon monoxide, lung diffusing capacity

KW - Gas exchange, diffusing capacity

KW - Mammals, humans

KW - Mediators, NO

UR - http://www.scopus.com/inward/record.url?scp=0034194725&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034194725&partnerID=8YFLogxK

U2 - 10.1016/S0034-5687(00)00104-3

DO - 10.1016/S0034-5687(00)00104-3

M3 - Article

C2 - 10828341

AN - SCOPUS:0034194725

VL - 120

SP - 251

EP - 271

JO - Respiratory Physiology and Neurobiology

JF - Respiratory Physiology and Neurobiology

SN - 1569-9048

IS - 3

ER -