Effect of aging on susceptibility of low-density lipoproteins to oxidation

A. Schmuck, C. J. Fuller, S. Devaraj, I. Jialal

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

According to the Adult Treatment Panel of the National Cholesterol Education Program, age is a major risk factor for heart disease. To assess the relation between age and LDL oxidizability, we studied copper-mediated LDL oxidation in 13 healthy elderly subjects (>59 years) and 13 sex-matched healthy young controls (<30 years). Total and LDL-cholesterol concentrations were increased in elderly subjects. The time course of copper-mediated LDL oxidation showed no significant differences between the two groups as assessed by formation of conjugated dienes, lipid peroxides, and apolipoprotein B fluorescence. Kinetics of LDL oxidation as quantified by lag time, oxidation rate, and maximal oxidation were not significantly different between the elderly and young groups. Although the concentrations of 16:0, 18:0, 18:1, 18:3, and 20:4 and total polyunsaturated fatty acids were significantly higher in the elderly group, LDL fatty acid concentrations were similar in both groups. Lipid-standardized α-tocopherol, β-carotene, and ascorbate concentrations were not significantly different between the two groups. The findings of the present study suggest that in the healthy elderly, LDL oxidation may not be a crucial mediator for atherogenesis.

Original languageEnglish (US)
Pages (from-to)1628-1632
Number of pages5
JournalClinical Chemistry
Volume41
Issue number11
StatePublished - 1995
Externally publishedYes

Keywords

  • antioxidants
  • atherogenesis
  • conjugated dienes
  • coronary artery disease
  • fatty acids
  • lipid peroxides
  • vitamins

ASJC Scopus subject areas

  • Clinical Biochemistry

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    Schmuck, A., Fuller, C. J., Devaraj, S., & Jialal, I. (1995). Effect of aging on susceptibility of low-density lipoproteins to oxidation. Clinical Chemistry, 41(11), 1628-1632.