Abstract
It has been suggested that genomic alterations involving DNA damage and the ability to repair such damage play an important role in cellular sensecence. In this study, endogenous DNA single-strand breaks, the susceptibility of DNA to induced strand breakage and the capacity to repair these breaks were compared in postmitotic cells from young (3-day-old) and old (23-day-old) houseflies. DNA single-strand breaks did not accumulate during normal aging in the housefly. However, cells of the old flies exhibited a greater sensitivity to single-strand breakage induced by γ-radiation and UV light. The capacity to repair these exogenously induced single-strand breaks declined with age. Results fo not support the view that DNA single-strand breaks are casual factor in aging in the housefly. An age-related increase in the susceptibility to undergo single-strand breakage suggests alterations in chromatin during the aging process.
Original language | English (US) |
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Pages (from-to) | 113-120 |
Number of pages | 8 |
Journal | Mutation Research DNAging |
Volume | 219 |
Issue number | 2 |
DOIs | |
State | Published - 1989 |
Externally published | Yes |
Keywords
- Aging
- DNA damage
- DNA repair
ASJC Scopus subject areas
- Aging
- Genetics
- Molecular Biology