Abstract
It has been suggested that genomic alterations involving DNA damage and the ability to repair such damage play an important role in cellular sensecence. In this study, endogenous DNA single-strand breaks, the susceptibility of DNA to induced strand breakage and the capacity to repair these breaks were compared in postmitotic cells from young (3-day-old) and old (23-day-old) houseflies. DNA single-strand breaks did not accumulate during normal aging in the housefly. However, cells of the old flies exhibited a greater sensitivity to single-strand breakage induced by γ-radiation and UV light. The capacity to repair these exogenously induced single-strand breaks declined with age. Results fo not support the view that DNA single-strand breaks are casual factor in aging in the housefly. An age-related increase in the susceptibility to undergo single-strand breakage suggests alterations in chromatin during the aging process.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 113-120 |
| Number of pages | 8 |
| Journal | Mutation Research DNAging |
| Volume | 219 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1989 |
| Externally published | Yes |
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Keywords
- Aging
- DNA damage
- DNA repair
ASJC Scopus subject areas
- Aging
- Genetics
- Molecular Biology
Cite this
Effect of age on endogenous DNA single-strand breakage, strand break induction and repair in the adult housefly, Musca domestica. / Newton, Ronald K.; Ducore, Jonathan M; Sohal, Rajindar S.
In: Mutation Research DNAging, Vol. 219, No. 2, 1989, p. 113-120.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of age on endogenous DNA single-strand breakage, strand break induction and repair in the adult housefly, Musca domestica
AU - Newton, Ronald K.
AU - Ducore, Jonathan M
AU - Sohal, Rajindar S.
PY - 1989
Y1 - 1989
N2 - It has been suggested that genomic alterations involving DNA damage and the ability to repair such damage play an important role in cellular sensecence. In this study, endogenous DNA single-strand breaks, the susceptibility of DNA to induced strand breakage and the capacity to repair these breaks were compared in postmitotic cells from young (3-day-old) and old (23-day-old) houseflies. DNA single-strand breaks did not accumulate during normal aging in the housefly. However, cells of the old flies exhibited a greater sensitivity to single-strand breakage induced by γ-radiation and UV light. The capacity to repair these exogenously induced single-strand breaks declined with age. Results fo not support the view that DNA single-strand breaks are casual factor in aging in the housefly. An age-related increase in the susceptibility to undergo single-strand breakage suggests alterations in chromatin during the aging process.
AB - It has been suggested that genomic alterations involving DNA damage and the ability to repair such damage play an important role in cellular sensecence. In this study, endogenous DNA single-strand breaks, the susceptibility of DNA to induced strand breakage and the capacity to repair these breaks were compared in postmitotic cells from young (3-day-old) and old (23-day-old) houseflies. DNA single-strand breaks did not accumulate during normal aging in the housefly. However, cells of the old flies exhibited a greater sensitivity to single-strand breakage induced by γ-radiation and UV light. The capacity to repair these exogenously induced single-strand breaks declined with age. Results fo not support the view that DNA single-strand breaks are casual factor in aging in the housefly. An age-related increase in the susceptibility to undergo single-strand breakage suggests alterations in chromatin during the aging process.
KW - Aging
KW - DNA damage
KW - DNA repair
UR - http://www.scopus.com/inward/record.url?scp=45249130372&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=45249130372&partnerID=8YFLogxK
U2 - 10.1016/0921-8734(89)90022-2
DO - 10.1016/0921-8734(89)90022-2
M3 - Article
C2 - 2927416
AN - SCOPUS:45249130372
VL - 219
SP - 113
EP - 120
JO - Mutation Research DNAging
JF - Mutation Research DNAging
SN - 0921-8734
IS - 2
ER -