Effect of acute maternal infection on quantity and composition of breast milk

Nelly Zavaleta, Claudio Lanata, Betzabe Butron, Janet M. Peerson, Kenneth H. Brown, Bo Lönnerdal

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

To investigate the potential effects of maternal infection during lactation on breast-milk quantity and composition, we examined low-income Peruvian women who had an acute febrile infection and were exclusively breast-feeding a child from 1 to 6 mo of age (n = 36). Women who were not ill (n = 38) served as controls; all women had body mass indexes (in kg/m2) > 19.5. Blood and milk samples were collected on days 1, 7, and 14 after identification of the episode of illness. C-reactive protein in maternal serum was significantly elevated by infection, whereas two other acute-phase reactants, ceruloplasmin and α2-macroglobulin, showed no change. Serum zinc concentrations were significantly lower in ill women than in women who were not ill, whereas serum copper concentrations were elevated initially in ill women. Serum iron concentrations increased significantly with time, but there was no significant difference between groups. Milk intake, as assessed by 12- h test-weighing, was not affected by the infection. Concentrations of milk total protein, casein, and whey proteins were similar in the two groups and there was no significant effect of illness on milk trace element concentrations. Thus, acute maternal infections during established lactation did not affect milk volume, milk protein, or trace element concentrations, despite expected changes in serum protein and trace element concentrations.

Original languageEnglish (US)
Pages (from-to)559-563
Number of pages5
JournalAmerican Journal of Clinical Nutrition
Volume62
Issue number3
StatePublished - Sep 1995

Fingerprint

Human Milk
breast milk
Mothers
blood serum
Milk
Trace Elements
Infection
infection
trace elements
milk
Milk Proteins
Serum
Lactation
lactation
macroglobulins
Macroglobulins
ferroxidase
Ceruloplasmin
acute phase proteins
Acute-Phase Proteins

Keywords

  • breast milk
  • copper
  • iron
  • lactation
  • Maternal infection
  • milk protein
  • milk volume
  • zinc

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Zavaleta, N., Lanata, C., Butron, B., Peerson, J. M., Brown, K. H., & Lönnerdal, B. (1995). Effect of acute maternal infection on quantity and composition of breast milk. American Journal of Clinical Nutrition, 62(3), 559-563.

Effect of acute maternal infection on quantity and composition of breast milk. / Zavaleta, Nelly; Lanata, Claudio; Butron, Betzabe; Peerson, Janet M.; Brown, Kenneth H.; Lönnerdal, Bo.

In: American Journal of Clinical Nutrition, Vol. 62, No. 3, 09.1995, p. 559-563.

Research output: Contribution to journalArticle

Zavaleta, N, Lanata, C, Butron, B, Peerson, JM, Brown, KH & Lönnerdal, B 1995, 'Effect of acute maternal infection on quantity and composition of breast milk', American Journal of Clinical Nutrition, vol. 62, no. 3, pp. 559-563.
Zavaleta N, Lanata C, Butron B, Peerson JM, Brown KH, Lönnerdal B. Effect of acute maternal infection on quantity and composition of breast milk. American Journal of Clinical Nutrition. 1995 Sep;62(3):559-563.
Zavaleta, Nelly ; Lanata, Claudio ; Butron, Betzabe ; Peerson, Janet M. ; Brown, Kenneth H. ; Lönnerdal, Bo. / Effect of acute maternal infection on quantity and composition of breast milk. In: American Journal of Clinical Nutrition. 1995 ; Vol. 62, No. 3. pp. 559-563.
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