Abstract
This study attempted to define the possible contribution of zinc nutrition to immunocompetence and growth in severely malnourished infants. The effect of zinc supplementation was evaluated in marasmic infants during nutritional rehabilitation by using a controlled double-blind design in which 19 infants fed a zinc-fortified formula were compared with 20 infants fed the same nonsupplemented formula. Evaluation of immunocompetence, growth, and zinc, copper, and iron status was performed on admission and at 30, 60, and 105 d of nutritional rehabilitation. Although energy intake was similar in both groups, the zinc-supplemented infants had significantly higher linear growth gain, and their immune function improved as demonstrated by conversion of their delayed hypersensitivity skin reactions, enhanced lymphoproliferative response to PHA. and increased salivary IgA concentrations. Thus, the use of a zinc-fortified formula during nutritional rehabilitation can prevent the development of zinc deficiency and improve growth and immune function.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 491-498 |
| Number of pages | 8 |
| Journal | American Journal of Clinical Nutrition |
| Volume | 56 |
| Issue number | 3 |
| State | Published - 1992 |
| Externally published | Yes |
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Keywords
- Cell-mediated immunity
- Delayed hypersensitivity
- Immune status
- Linear growth
- Malnutrition
- Phytohemagglutinin
- Secretory IgA
- Zinc nutrition
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Food Science
Cite this
Effect of a zinc-fortified formula on immunocompetence and growth of malnourished infants. / Schlesinger, Liana; Arevalo, Marianela; Arredondo, Sonia; Diaz, Mirtha; Lönnerdal, Bo; Stekel, Abraham.
In: American Journal of Clinical Nutrition, Vol. 56, No. 3, 1992, p. 491-498.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of a zinc-fortified formula on immunocompetence and growth of malnourished infants
AU - Schlesinger, Liana
AU - Arevalo, Marianela
AU - Arredondo, Sonia
AU - Diaz, Mirtha
AU - Lönnerdal, Bo
AU - Stekel, Abraham
PY - 1992
Y1 - 1992
N2 - This study attempted to define the possible contribution of zinc nutrition to immunocompetence and growth in severely malnourished infants. The effect of zinc supplementation was evaluated in marasmic infants during nutritional rehabilitation by using a controlled double-blind design in which 19 infants fed a zinc-fortified formula were compared with 20 infants fed the same nonsupplemented formula. Evaluation of immunocompetence, growth, and zinc, copper, and iron status was performed on admission and at 30, 60, and 105 d of nutritional rehabilitation. Although energy intake was similar in both groups, the zinc-supplemented infants had significantly higher linear growth gain, and their immune function improved as demonstrated by conversion of their delayed hypersensitivity skin reactions, enhanced lymphoproliferative response to PHA. and increased salivary IgA concentrations. Thus, the use of a zinc-fortified formula during nutritional rehabilitation can prevent the development of zinc deficiency and improve growth and immune function.
AB - This study attempted to define the possible contribution of zinc nutrition to immunocompetence and growth in severely malnourished infants. The effect of zinc supplementation was evaluated in marasmic infants during nutritional rehabilitation by using a controlled double-blind design in which 19 infants fed a zinc-fortified formula were compared with 20 infants fed the same nonsupplemented formula. Evaluation of immunocompetence, growth, and zinc, copper, and iron status was performed on admission and at 30, 60, and 105 d of nutritional rehabilitation. Although energy intake was similar in both groups, the zinc-supplemented infants had significantly higher linear growth gain, and their immune function improved as demonstrated by conversion of their delayed hypersensitivity skin reactions, enhanced lymphoproliferative response to PHA. and increased salivary IgA concentrations. Thus, the use of a zinc-fortified formula during nutritional rehabilitation can prevent the development of zinc deficiency and improve growth and immune function.
KW - Cell-mediated immunity
KW - Delayed hypersensitivity
KW - Immune status
KW - Linear growth
KW - Malnutrition
KW - Phytohemagglutinin
KW - Secretory IgA
KW - Zinc nutrition
UR - http://www.scopus.com/inward/record.url?scp=0026806680&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026806680&partnerID=8YFLogxK
M3 - Article
C2 - 1503059
AN - SCOPUS:0026806680
VL - 56
SP - 491
EP - 498
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 3
ER -