Effect of a cellulose acetate phthalate topical cream on vaginal transmission of simian immunodeficiency virus in rhesus monkeys

K. H. Manson, M. S. Wyand, Chris J Miller, A. R. Neurath

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

Human immunodeficiency virus type 1 (HIV-1) infection continues to spread in developing countries, mostly through heterosexual transmission. The development of a safe and cost-effective topical microbicide, effective against a range of STDs including HIV-1, would greatly impact the ongoing epidemic. When formulated in a vehicle, a micronized form of cellulose acetate phthalate (CAP), which is an inactive pharmaceutical excipient, has been shown to inactivate HIV-1, herpes simplex virus types 1 and 2, cytomegalovirus, Neisseria gonorrhoeae, Trichomonas vaginalis, Haemophilus ducreyi, and Chlamydia trachomatis in vitro. Formulated CAP was also shown to be effective against herpes simplex virus type 2 in vivo. Here we show that a formulation of CAP protected four of six rhesus monkeys from vaginal infection with simian immunodeficiency virus. Thus, CAP may be a candidate for use as a topical microbicide for preventing HIV-1 infection in humans.

Original languageEnglish (US)
Pages (from-to)3199-3202
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume44
Issue number11
DOIs
StatePublished - 2000
Externally publishedYes

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ASJC Scopus subject areas

  • Pharmacology (medical)

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