Effect of a cellulose acetate phthalate topical cream on vaginal transmission of simian immunodeficiency virus in rhesus monkeys

K. H. Manson, M. S. Wyand, Chris J Miller, A. R. Neurath

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Human immunodeficiency virus type 1 (HIV-1) infection continues to spread in developing countries, mostly through heterosexual transmission. The development of a safe and cost-effective topical microbicide, effective against a range of STDs including HIV-1, would greatly impact the ongoing epidemic. When formulated in a vehicle, a micronized form of cellulose acetate phthalate (CAP), which is an inactive pharmaceutical excipient, has been shown to inactivate HIV-1, herpes simplex virus types 1 and 2, cytomegalovirus, Neisseria gonorrhoeae, Trichomonas vaginalis, Haemophilus ducreyi, and Chlamydia trachomatis in vitro. Formulated CAP was also shown to be effective against herpes simplex virus type 2 in vivo. Here we show that a formulation of CAP protected four of six rhesus monkeys from vaginal infection with simian immunodeficiency virus. Thus, CAP may be a candidate for use as a topical microbicide for preventing HIV-1 infection in humans.

Original languageEnglish (US)
Pages (from-to)3199-3202
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume44
Issue number11
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Foams and Jellies Vaginal Creams
Simian Immunodeficiency Virus
Macaca mulatta
HIV-1
Local Anti-Infective Agents
Human Herpesvirus 2
Virus Diseases
Haemophilus ducreyi
Trichomonas vaginalis
Neisseria gonorrhoeae
Excipients
Chlamydia trachomatis
Heterosexuality
Human Herpesvirus 1
Sexually Transmitted Diseases
Cytomegalovirus
Developing Countries
Costs and Cost Analysis
cellulose acetate phthalate
Infection

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Effect of a cellulose acetate phthalate topical cream on vaginal transmission of simian immunodeficiency virus in rhesus monkeys. / Manson, K. H.; Wyand, M. S.; Miller, Chris J; Neurath, A. R.

In: Antimicrobial Agents and Chemotherapy, Vol. 44, No. 11, 2000, p. 3199-3202.

Research output: Contribution to journalArticle

@article{1567aa56d06541bba17d5f542402406f,
title = "Effect of a cellulose acetate phthalate topical cream on vaginal transmission of simian immunodeficiency virus in rhesus monkeys",
abstract = "Human immunodeficiency virus type 1 (HIV-1) infection continues to spread in developing countries, mostly through heterosexual transmission. The development of a safe and cost-effective topical microbicide, effective against a range of STDs including HIV-1, would greatly impact the ongoing epidemic. When formulated in a vehicle, a micronized form of cellulose acetate phthalate (CAP), which is an inactive pharmaceutical excipient, has been shown to inactivate HIV-1, herpes simplex virus types 1 and 2, cytomegalovirus, Neisseria gonorrhoeae, Trichomonas vaginalis, Haemophilus ducreyi, and Chlamydia trachomatis in vitro. Formulated CAP was also shown to be effective against herpes simplex virus type 2 in vivo. Here we show that a formulation of CAP protected four of six rhesus monkeys from vaginal infection with simian immunodeficiency virus. Thus, CAP may be a candidate for use as a topical microbicide for preventing HIV-1 infection in humans.",
author = "Manson, {K. H.} and Wyand, {M. S.} and Miller, {Chris J} and Neurath, {A. R.}",
year = "2000",
doi = "10.1128/AAC.44.11.3199-3202.2000",
language = "English (US)",
volume = "44",
pages = "3199--3202",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "11",

}

TY - JOUR

T1 - Effect of a cellulose acetate phthalate topical cream on vaginal transmission of simian immunodeficiency virus in rhesus monkeys

AU - Manson, K. H.

AU - Wyand, M. S.

AU - Miller, Chris J

AU - Neurath, A. R.

PY - 2000

Y1 - 2000

N2 - Human immunodeficiency virus type 1 (HIV-1) infection continues to spread in developing countries, mostly through heterosexual transmission. The development of a safe and cost-effective topical microbicide, effective against a range of STDs including HIV-1, would greatly impact the ongoing epidemic. When formulated in a vehicle, a micronized form of cellulose acetate phthalate (CAP), which is an inactive pharmaceutical excipient, has been shown to inactivate HIV-1, herpes simplex virus types 1 and 2, cytomegalovirus, Neisseria gonorrhoeae, Trichomonas vaginalis, Haemophilus ducreyi, and Chlamydia trachomatis in vitro. Formulated CAP was also shown to be effective against herpes simplex virus type 2 in vivo. Here we show that a formulation of CAP protected four of six rhesus monkeys from vaginal infection with simian immunodeficiency virus. Thus, CAP may be a candidate for use as a topical microbicide for preventing HIV-1 infection in humans.

AB - Human immunodeficiency virus type 1 (HIV-1) infection continues to spread in developing countries, mostly through heterosexual transmission. The development of a safe and cost-effective topical microbicide, effective against a range of STDs including HIV-1, would greatly impact the ongoing epidemic. When formulated in a vehicle, a micronized form of cellulose acetate phthalate (CAP), which is an inactive pharmaceutical excipient, has been shown to inactivate HIV-1, herpes simplex virus types 1 and 2, cytomegalovirus, Neisseria gonorrhoeae, Trichomonas vaginalis, Haemophilus ducreyi, and Chlamydia trachomatis in vitro. Formulated CAP was also shown to be effective against herpes simplex virus type 2 in vivo. Here we show that a formulation of CAP protected four of six rhesus monkeys from vaginal infection with simian immunodeficiency virus. Thus, CAP may be a candidate for use as a topical microbicide for preventing HIV-1 infection in humans.

UR - http://www.scopus.com/inward/record.url?scp=0033752419&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033752419&partnerID=8YFLogxK

U2 - 10.1128/AAC.44.11.3199-3202.2000

DO - 10.1128/AAC.44.11.3199-3202.2000

M3 - Article

VL - 44

SP - 3199

EP - 3202

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 11

ER -