Abstract
6-Mercaptopurine ribonucleoside 5'-triphosphate was found to be an inhibitor of DNA-dependent RNA polymerases from Escherichia coli and chicken myeloblastosis cells. The inhibitor appears to compete with GTP for its binding to RNA polymerase, resulting in a reduction of RNA chain initiations. Neither 6-mercaptopurine ribonucleoside nor its monophosphate derivative caused the inhibition. These studies suggest that the antineoplastic action of 6-mercaptopurine may in part be owing to the inhibition of the activity of DNA-dependent RNA polymerase, resulting in an inhibition of cellular RNA synthesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 503-506 |
| Number of pages | 4 |
| Journal | Molecular Pharmacology |
| Volume | 18 |
| Issue number | 3 |
| State | Published - Dec 1 1980 |
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology
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Cite this
Kawahata, R. T., Holmberg, C. A., Osburn, B., Chuang, L. F., & Chuang, R. Y. (1980). Effect of 6-mercaptopurine ribonucleotides on DNA-dependent RNA polymerase activity. Molecular Pharmacology, 18(3), 503-506.