Effect of 6-hydroxydopamine lesions on norepinephrine-induced [3H]glycogen hydrolysis in mouse cortical slices

Pierre J. Magistretti, John Morrison, William J. Shoemaker, Floyd E. Bloom

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

The effects of norepinephrine (NE) on in vitro [3H]glycogenolysis were assessed in slices of cerebral cortex from mice whose cortical noradrenergic innervation had been severely reduced by intracisternal 6-hydroxydopamine (6-OHDA) injections. A supersensitive response to NE was observed, as demonstrated by a decrease in the EC50 of the catecholamine in the lesioned mice from 533 ± 88 nM to 39.3 ± 7.9 nM. This supersensitive response, observed two weeks after the lesion, was post-synaptic since isoproterenol, a β-adrenergic agonist not accumulated by pre-synaptic uptake mechanisms, also gave an equally supersensitive response.

Original languageEnglish (US)
Pages (from-to)159-162
Number of pages4
JournalBrain Research
Volume261
Issue number1
DOIs
StatePublished - Feb 14 1983
Externally publishedYes

Keywords

  • adrenergic receptors
  • brain energy metabolism
  • cerebral cortex
  • cyclic-AMP
  • glycogen
  • supersensitivity

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Developmental Biology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Effect of 6-hydroxydopamine lesions on norepinephrine-induced [<sup>3</sup>H]glycogen hydrolysis in mouse cortical slices'. Together they form a unique fingerprint.

  • Cite this