Effect of 6-hydroxydopamine lesions on norepinephrine-induced [3H]glycogen hydrolysis in mouse cortical slices

Pierre J. Magistretti, John Morrison, William J. Shoemaker, Floyd E. Bloom

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The effects of norepinephrine (NE) on in vitro [3H]glycogenolysis were assessed in slices of cerebral cortex from mice whose cortical noradrenergic innervation had been severely reduced by intracisternal 6-hydroxydopamine (6-OHDA) injections. A supersensitive response to NE was observed, as demonstrated by a decrease in the EC50 of the catecholamine in the lesioned mice from 533 ± 88 nM to 39.3 ± 7.9 nM. This supersensitive response, observed two weeks after the lesion, was post-synaptic since isoproterenol, a β-adrenergic agonist not accumulated by pre-synaptic uptake mechanisms, also gave an equally supersensitive response.

Original languageEnglish (US)
Pages (from-to)159-162
Number of pages4
JournalBrain Research
Volume261
Issue number1
DOIs
StatePublished - Feb 14 1983
Externally publishedYes

Fingerprint

Oxidopamine
Glycogen
Norepinephrine
Hydrolysis
Glycogenolysis
Adrenergic Agonists
Isoproterenol
Cerebral Cortex
Catecholamines
Injections
In Vitro Techniques

Keywords

  • adrenergic receptors
  • brain energy metabolism
  • cerebral cortex
  • cyclic-AMP
  • glycogen
  • supersensitivity

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Developmental Biology
  • Clinical Neurology

Cite this

Effect of 6-hydroxydopamine lesions on norepinephrine-induced [3H]glycogen hydrolysis in mouse cortical slices. / Magistretti, Pierre J.; Morrison, John; Shoemaker, William J.; Bloom, Floyd E.

In: Brain Research, Vol. 261, No. 1, 14.02.1983, p. 159-162.

Research output: Contribution to journalArticle

Magistretti, Pierre J. ; Morrison, John ; Shoemaker, William J. ; Bloom, Floyd E. / Effect of 6-hydroxydopamine lesions on norepinephrine-induced [3H]glycogen hydrolysis in mouse cortical slices. In: Brain Research. 1983 ; Vol. 261, No. 1. pp. 159-162.
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