TY - JOUR
T1 - EEG Abnormalities as a Neurophysiological Biomarker of Severity in Autism Spectrum Disorder
T2 - A Pilot Cohort Study
AU - Nicotera, Antonio Gennaro
AU - Hagerman, Randi J
AU - Catania, Maria Vincenza
AU - Buono, Serafino
AU - Di Nuovo, Santo
AU - Liprino, Elisa Maria
AU - Stracuzzi, Emanuela
AU - Giusto, Stefania
AU - Di Vita, Giuseppina
AU - Musumeci, Sebastiano Antonino
PY - 2019/1/1
Y1 - 2019/1/1
N2 - To date, the phenotypic significance of EEG abnormalities in patients with ASD is unclear. In a population affected by ASD we aimed to evaluate: the phenotypic characteristics; the prevalence of EEG abnormalities; the potential correlations between EEG abnormalities and behavioral and cognitive variables. Sixty-nine patients with ASD underwent cognitive or developmental testing, language assessment, and adaptive behavior skills evaluation as well as sleep/wake EEG recording. EEG abnormalities were found in 39.13% of patients. EEG abnormalities correlated with autism severity, hyperactivity, anger outbursts, aggression, negative or destructive behavior, motor stereotypies, intellectual disability, language impairment and self-harm. Our findings confirmed that EEG abnormalities are present in the ASD population and correlate with several associated phenotypic features.
AB - To date, the phenotypic significance of EEG abnormalities in patients with ASD is unclear. In a population affected by ASD we aimed to evaluate: the phenotypic characteristics; the prevalence of EEG abnormalities; the potential correlations between EEG abnormalities and behavioral and cognitive variables. Sixty-nine patients with ASD underwent cognitive or developmental testing, language assessment, and adaptive behavior skills evaluation as well as sleep/wake EEG recording. EEG abnormalities were found in 39.13% of patients. EEG abnormalities correlated with autism severity, hyperactivity, anger outbursts, aggression, negative or destructive behavior, motor stereotypies, intellectual disability, language impairment and self-harm. Our findings confirmed that EEG abnormalities are present in the ASD population and correlate with several associated phenotypic features.
KW - Autism spectrum disorder
KW - Biomarker
KW - Epileptiform abnormalities
KW - Hyperactivity
KW - Phenotype
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U2 - 10.1007/s10803-019-03908-2
DO - 10.1007/s10803-019-03908-2
M3 - Article
C2 - 30726535
AN - SCOPUS:85061186073
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
SN - 0162-3257
ER -