Edrophonium: An aid in the diagnosis of acute organophosphate poisoning

Ricardo A Maselli, J. H. Jacobsen, J. P. Spire

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Unsuspected accidental cutaneous exposure to an organophosphate insecticide caused flaccid paralysis in a 10-year-old girl. Electromyogram demonstrated repetitive compound muscle action potentials in response to a single stimulus of nerve; decremental response, more prominent at higher rates of stimulation; worsening of decremental response after edrophonium injection; and normal nerve conduction velocities. Electromyogram with repetitive nerve stimulation and an edrophonium test may provide a simple and rapid method for diagnosis of acute organophosphate poisoning.

Original languageEnglish (US)
Pages (from-to)508-510
Number of pages3
JournalAnnals of Neurology
Issue number5
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


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