Abstract
Obiective - To evaluate the decision to test for milk antimicrobial residues in milk from dairy cows treated with procaine penicillin G (PPG). Design-Economic-decision analysis after stochasic simulation. Sample Population - 1,000 computer-simulated cows/model. Procedure - Meta-analysis of the Food Animal Residue Avoidance Databank was used to generate PPG disappearance curves for cows given single PPG treatments IM of 6,600 U/kg (3,000 U/lb) of body weight or 26,400 U/kg (12,000 U/lb), and multiple treatments at 26,400 U/kg (12,000 U/lb), IM. These curves were entered into 1,000-replication stochastic Pharmacokinetic models, generating population-level milk PPG profiles for each treatment group for each day after treatment, which were subjected to economic-decision analyses of feasibility of residue testing. The model was evaluated for changes in herd size, proportion of herd available for testing, milk production test price, test sensitivity/specificity, and withdrawal periods. Results - For both single-treatment groups, a 2-day withdrawal period avoided violative residues. However, nearly two thirds of the cows risked false identification for violative residues. For the multiple-treated group, nearly 40% had violative residues after a 5-day withdrawal period, and an additional 10 to 15% risked false identification for violative residues. Economic analysis yielded a decision against testing mean cost was $2 (ie, 5% more than the mean cost of not testing). Clinical Implications - Complex dynamics of current milk residue tests discourage practitioners from recommending procedures to clients. In general increases in herd size, milk production, proportion of a herd available for testing, or milk price will increase the value of testing. Increasing test sensitivity decreases its desirability to producers.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 419-427 |
| Number of pages | 9 |
| Journal | Journal of the American Veterinary Medical Association |
| Volume | 211 |
| Issue number | 4 |
| State | Published - Aug 15 1997 |
Fingerprint
ASJC Scopus subject areas
- veterinary(all)
Cite this
Economic evaluation of risks to producers who use milk residue testing programs. / Slenning, Barrett Durand; Gardner, Ian.
In: Journal of the American Veterinary Medical Association, Vol. 211, No. 4, 15.08.1997, p. 419-427.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Economic evaluation of risks to producers who use milk residue testing programs
AU - Slenning, Barrett Durand
AU - Gardner, Ian
PY - 1997/8/15
Y1 - 1997/8/15
N2 - Obiective - To evaluate the decision to test for milk antimicrobial residues in milk from dairy cows treated with procaine penicillin G (PPG). Design-Economic-decision analysis after stochasic simulation. Sample Population - 1,000 computer-simulated cows/model. Procedure - Meta-analysis of the Food Animal Residue Avoidance Databank was used to generate PPG disappearance curves for cows given single PPG treatments IM of 6,600 U/kg (3,000 U/lb) of body weight or 26,400 U/kg (12,000 U/lb), and multiple treatments at 26,400 U/kg (12,000 U/lb), IM. These curves were entered into 1,000-replication stochastic Pharmacokinetic models, generating population-level milk PPG profiles for each treatment group for each day after treatment, which were subjected to economic-decision analyses of feasibility of residue testing. The model was evaluated for changes in herd size, proportion of herd available for testing, milk production test price, test sensitivity/specificity, and withdrawal periods. Results - For both single-treatment groups, a 2-day withdrawal period avoided violative residues. However, nearly two thirds of the cows risked false identification for violative residues. For the multiple-treated group, nearly 40% had violative residues after a 5-day withdrawal period, and an additional 10 to 15% risked false identification for violative residues. Economic analysis yielded a decision against testing mean cost was $2 (ie, 5% more than the mean cost of not testing). Clinical Implications - Complex dynamics of current milk residue tests discourage practitioners from recommending procedures to clients. In general increases in herd size, milk production, proportion of a herd available for testing, or milk price will increase the value of testing. Increasing test sensitivity decreases its desirability to producers.
AB - Obiective - To evaluate the decision to test for milk antimicrobial residues in milk from dairy cows treated with procaine penicillin G (PPG). Design-Economic-decision analysis after stochasic simulation. Sample Population - 1,000 computer-simulated cows/model. Procedure - Meta-analysis of the Food Animal Residue Avoidance Databank was used to generate PPG disappearance curves for cows given single PPG treatments IM of 6,600 U/kg (3,000 U/lb) of body weight or 26,400 U/kg (12,000 U/lb), and multiple treatments at 26,400 U/kg (12,000 U/lb), IM. These curves were entered into 1,000-replication stochastic Pharmacokinetic models, generating population-level milk PPG profiles for each treatment group for each day after treatment, which were subjected to economic-decision analyses of feasibility of residue testing. The model was evaluated for changes in herd size, proportion of herd available for testing, milk production test price, test sensitivity/specificity, and withdrawal periods. Results - For both single-treatment groups, a 2-day withdrawal period avoided violative residues. However, nearly two thirds of the cows risked false identification for violative residues. For the multiple-treated group, nearly 40% had violative residues after a 5-day withdrawal period, and an additional 10 to 15% risked false identification for violative residues. Economic analysis yielded a decision against testing mean cost was $2 (ie, 5% more than the mean cost of not testing). Clinical Implications - Complex dynamics of current milk residue tests discourage practitioners from recommending procedures to clients. In general increases in herd size, milk production, proportion of a herd available for testing, or milk price will increase the value of testing. Increasing test sensitivity decreases its desirability to producers.
UR - http://www.scopus.com/inward/record.url?scp=0031571239&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031571239&partnerID=8YFLogxK
M3 - Article
C2 - 9267502
AN - SCOPUS:0031571239
VL - 211
SP - 419
EP - 427
JO - Journal of the American Veterinary Medical Association
JF - Journal of the American Veterinary Medical Association
SN - 0003-1488
IS - 4
ER -