Ecological validity and neuroanatomical correlates of the NIH EXAMINER executive composite score

Katherine L. Possin, Amanda K. LaMarre, Kristie A. Wood, Dan M Mungas, Joel H. Kramer

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Executive functions refer to a constellation of higher-level cognitive abilities that enable goal-oriented behavior. The NIH EXAMINER battery was designed to assess executive functions comprehensively and efficiently. Performance can be summarized by a single score, the Executive Composite, which combines measures of inhibition, set-shifting, fluency, and working memory. We evaluated the ecological validity of the Executive Composite in a sample of 225 mixed neurological patients and controls using the Frontal Systems Behavior Scale (FrSBe), an informant-based measure of real-world executive behavior. In addition, we investigated the neuroanatomical correlates of the Executive Composite using voxel-based morphometry in a sample of 37 participants diagnosed with dementia, mild cognitive impairment, or as neurologically healthy. The Executive Composite accounted for 28% of the variance in Frontal Systems Behavior Scale scores beyond age. Even after including two widely used executive function tests (Trails B and Stroop) as covariates, the Executive Composite remained a significant predictor of real-world behavior. Anatomically, poorer scores on the Executive Composite were associated with smaller right and left dorsolateral prefrontal volumes, brain regions critical for good executive control. Taken together, these results suggest that the Executive Composite measures important aspects of executive function not captured by standard measures and reflects the integrity of frontal systems. (JINS, 2013, 19, 1-9)

Original languageEnglish (US)
Pages (from-to)20-28
Number of pages9
JournalJournal of the International Neuropsychological Society
Volume20
Issue number1
DOIs
StatePublished - Jan 2014

Keywords

  • Executive function
  • Magnetic resonance imaging
  • Neurodegenerative disorders
  • Neurological disorders
  • Prefrontal cortex
  • Validity of results

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Clinical Psychology
  • Neuroscience(all)
  • Language and Linguistics
  • Linguistics and Language

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