ECK, a human EPH-related gene, maps to 1p36.1, a common region of alteration in human cancers

Erik P. Sulman, Xao X. Tang, Cindy Allen, Jaclyn A. Biegel, David E Pleasure, Garrett M. Brodeur, Naohiko Ikegaki

Research output: Contribution to journalArticle

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Abstract

Mouse eck, a member of the EPH gene family, has been mapped to mouse chromosome 4. The syntenic relationship between this chromosome and human chromosome 1 suggests that the human ECK gene maps to the distal short arm of human chromosome 1 (1p). Since this region is frequently deleted or altered in certain tumors of neuroectodermal origin, it is important to define the specific chromosomal localization of the human ECK gene. PCR screening of a rodent-human somatic cell hybrid panel by ECK-specific primers showed that ECK is indeed localized to human chromosome 1. Additional PCR screening of a regional screening panel for chromosome 1p indicated that ECK is localized to 1p36, distal to FUCA1. Furthermore, fluorescence in situ hybridization analysis with an ECK-specific P1 clone showed that ECK maps proximal to genetic marker D1S228. Taken together, the data suggest that ECK maps to 1p36.1, a region that is frequently deleted in neuroblastoma, melanoma, and other neuroectodermal tumors.

Original languageEnglish (US)
Pages (from-to)371-374
Number of pages4
JournalGenomics
Volume40
Issue number2
DOIs
StatePublished - Mar 1 1997
Externally publishedYes

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Chromosomes, Human, Pair 1
Human Chromosomes
Neuroectodermal Tumors
Chromosomes
Genes
Neoplasms
Polymerase Chain Reaction
Chromosomes, Human, Pair 4
Hybrid Cells
Fluorescence In Situ Hybridization
Neuroblastoma
Genetic Markers
Rodentia
Melanoma
Clone Cells

ASJC Scopus subject areas

  • Genetics

Cite this

Sulman, E. P., Tang, X. X., Allen, C., Biegel, J. A., Pleasure, D. E., Brodeur, G. M., & Ikegaki, N. (1997). ECK, a human EPH-related gene, maps to 1p36.1, a common region of alteration in human cancers. Genomics, 40(2), 371-374. https://doi.org/10.1006/geno.1996.4569

ECK, a human EPH-related gene, maps to 1p36.1, a common region of alteration in human cancers. / Sulman, Erik P.; Tang, Xao X.; Allen, Cindy; Biegel, Jaclyn A.; Pleasure, David E; Brodeur, Garrett M.; Ikegaki, Naohiko.

In: Genomics, Vol. 40, No. 2, 01.03.1997, p. 371-374.

Research output: Contribution to journalArticle

Sulman, EP, Tang, XX, Allen, C, Biegel, JA, Pleasure, DE, Brodeur, GM & Ikegaki, N 1997, 'ECK, a human EPH-related gene, maps to 1p36.1, a common region of alteration in human cancers', Genomics, vol. 40, no. 2, pp. 371-374. https://doi.org/10.1006/geno.1996.4569
Sulman, Erik P. ; Tang, Xao X. ; Allen, Cindy ; Biegel, Jaclyn A. ; Pleasure, David E ; Brodeur, Garrett M. ; Ikegaki, Naohiko. / ECK, a human EPH-related gene, maps to 1p36.1, a common region of alteration in human cancers. In: Genomics. 1997 ; Vol. 40, No. 2. pp. 371-374.
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