Abstract
OBJECTIVE: To quantify drug-induced changes in right ventricular (RV) systolic function after administration of pimobendan and atenolol.
ANIMALS: 80 healthy privately-owned dogs.
METHODS: Using a prospective, blinded, fully-crossed study design with randomized drug administration, RV systolic function was determined twice at two time periods; before and 3 h after administration of pimobendan (0.25 mg/kg PO) or atenolol (1 mg/kg PO). Indices of RV systolic function included tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC), pulsed-wave tissue Doppler-derived systolic myocardial velocity of the lateral tricuspid annulus (S'), and speckle-tracking-derived global longitudinal RV free wall strain and strain rate. The effect of treatment on percent change from baseline RV function was analyzed with a linear mixed model including the covariates heart rate, body weight, age, gender, drug sequence, and time period.
RESULTS: All indices showed a significant (p < 0.0001) increase and decrease from baseline following pimobendan and atenolol, respectively. Significant differences from baseline were attributed to drug treatment (p < 0.0001); whereas, effects of other covariates were not significant. The greatest percent changes, but also highest variability, were observed for S' and strain rate (p < 0.0001). Post-atenolol, a significantly greater proportion of dogs exceeded the repeatability coefficient of variation for FAC and S' compared to TAPSE (p ≤ 0.007).
CONCLUSIONS: Echocardiographic indices in healthy dogs tracked expected changes in RV systolic function following pimobendan and atenolol and warrant study in dogs with cardiovascular disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 161-172 |
| Number of pages | 12 |
| Journal | Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology |
| Volume | 17 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 1 2015 |
| Externally published | Yes |
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Keywords
- Canine
- Cardiac
- Echocardiography
- Ultrasound
ASJC Scopus subject areas
- Physiology
- veterinary(all)
Cite this
Echocardiographic assessment of right ventricular systolic function in conscious healthy dogs following a single dose of pimobendan versus atenolol. / Visser, Lance C; Scansen, Brian A.; Brown, Nicole V.; Schober, Karsten E.; Bonagura, John D.
In: Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology, Vol. 17, No. 3, 01.09.2015, p. 161-172.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Echocardiographic assessment of right ventricular systolic function in conscious healthy dogs following a single dose of pimobendan versus atenolol
AU - Visser, Lance C
AU - Scansen, Brian A.
AU - Brown, Nicole V.
AU - Schober, Karsten E.
AU - Bonagura, John D.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - OBJECTIVE: To quantify drug-induced changes in right ventricular (RV) systolic function after administration of pimobendan and atenolol.ANIMALS: 80 healthy privately-owned dogs.METHODS: Using a prospective, blinded, fully-crossed study design with randomized drug administration, RV systolic function was determined twice at two time periods; before and 3 h after administration of pimobendan (0.25 mg/kg PO) or atenolol (1 mg/kg PO). Indices of RV systolic function included tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC), pulsed-wave tissue Doppler-derived systolic myocardial velocity of the lateral tricuspid annulus (S'), and speckle-tracking-derived global longitudinal RV free wall strain and strain rate. The effect of treatment on percent change from baseline RV function was analyzed with a linear mixed model including the covariates heart rate, body weight, age, gender, drug sequence, and time period.RESULTS: All indices showed a significant (p < 0.0001) increase and decrease from baseline following pimobendan and atenolol, respectively. Significant differences from baseline were attributed to drug treatment (p < 0.0001); whereas, effects of other covariates were not significant. The greatest percent changes, but also highest variability, were observed for S' and strain rate (p < 0.0001). Post-atenolol, a significantly greater proportion of dogs exceeded the repeatability coefficient of variation for FAC and S' compared to TAPSE (p ≤ 0.007).CONCLUSIONS: Echocardiographic indices in healthy dogs tracked expected changes in RV systolic function following pimobendan and atenolol and warrant study in dogs with cardiovascular disease.
AB - OBJECTIVE: To quantify drug-induced changes in right ventricular (RV) systolic function after administration of pimobendan and atenolol.ANIMALS: 80 healthy privately-owned dogs.METHODS: Using a prospective, blinded, fully-crossed study design with randomized drug administration, RV systolic function was determined twice at two time periods; before and 3 h after administration of pimobendan (0.25 mg/kg PO) or atenolol (1 mg/kg PO). Indices of RV systolic function included tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC), pulsed-wave tissue Doppler-derived systolic myocardial velocity of the lateral tricuspid annulus (S'), and speckle-tracking-derived global longitudinal RV free wall strain and strain rate. The effect of treatment on percent change from baseline RV function was analyzed with a linear mixed model including the covariates heart rate, body weight, age, gender, drug sequence, and time period.RESULTS: All indices showed a significant (p < 0.0001) increase and decrease from baseline following pimobendan and atenolol, respectively. Significant differences from baseline were attributed to drug treatment (p < 0.0001); whereas, effects of other covariates were not significant. The greatest percent changes, but also highest variability, were observed for S' and strain rate (p < 0.0001). Post-atenolol, a significantly greater proportion of dogs exceeded the repeatability coefficient of variation for FAC and S' compared to TAPSE (p ≤ 0.007).CONCLUSIONS: Echocardiographic indices in healthy dogs tracked expected changes in RV systolic function following pimobendan and atenolol and warrant study in dogs with cardiovascular disease.
KW - Canine
KW - Cardiac
KW - Echocardiography
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=84968838481&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84968838481&partnerID=8YFLogxK
U2 - 10.1016/j.jvc.2015.04.001
DO - 10.1016/j.jvc.2015.04.001
M3 - Article
VL - 17
SP - 161
EP - 172
JO - Journal of Veterinary Cardiology
JF - Journal of Veterinary Cardiology
SN - 1760-2734
IS - 3
ER -