Echocardiographic assessment of right ventricular systolic function in conscious healthy dogs following a single dose of pimobendan versus atenolol

Lance C Visser, Brian A. Scansen, Nicole V. Brown, Karsten E. Schober, John D. Bonagura

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

OBJECTIVE: To quantify drug-induced changes in right ventricular (RV) systolic function after administration of pimobendan and atenolol.

ANIMALS: 80 healthy privately-owned dogs.

METHODS: Using a prospective, blinded, fully-crossed study design with randomized drug administration, RV systolic function was determined twice at two time periods; before and 3 h after administration of pimobendan (0.25 mg/kg PO) or atenolol (1 mg/kg PO). Indices of RV systolic function included tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC), pulsed-wave tissue Doppler-derived systolic myocardial velocity of the lateral tricuspid annulus (S'), and speckle-tracking-derived global longitudinal RV free wall strain and strain rate. The effect of treatment on percent change from baseline RV function was analyzed with a linear mixed model including the covariates heart rate, body weight, age, gender, drug sequence, and time period.

RESULTS: All indices showed a significant (p < 0.0001) increase and decrease from baseline following pimobendan and atenolol, respectively. Significant differences from baseline were attributed to drug treatment (p < 0.0001); whereas, effects of other covariates were not significant. The greatest percent changes, but also highest variability, were observed for S' and strain rate (p < 0.0001). Post-atenolol, a significantly greater proportion of dogs exceeded the repeatability coefficient of variation for FAC and S' compared to TAPSE (p ≤ 0.007).

CONCLUSIONS: Echocardiographic indices in healthy dogs tracked expected changes in RV systolic function following pimobendan and atenolol and warrant study in dogs with cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)161-172
Number of pages12
JournalJournal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology
Volume17
Issue number3
DOIs
StatePublished - Sep 1 2015
Externally publishedYes

Fingerprint

Right Ventricular Function
Atenolol
Dogs
dogs
dosage
drugs
Pharmaceutical Preparations
repeatability
cardiovascular diseases
drug therapy
heart rate
experimental design
Linear Models
Cardiovascular Diseases
Heart Rate
body weight
Body Weight
pimobendan
gender

Keywords

  • Canine
  • Cardiac
  • Echocardiography
  • Ultrasound

ASJC Scopus subject areas

  • Physiology
  • veterinary(all)

Cite this

Echocardiographic assessment of right ventricular systolic function in conscious healthy dogs following a single dose of pimobendan versus atenolol. / Visser, Lance C; Scansen, Brian A.; Brown, Nicole V.; Schober, Karsten E.; Bonagura, John D.

In: Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology, Vol. 17, No. 3, 01.09.2015, p. 161-172.

Research output: Contribution to journalArticle

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abstract = "OBJECTIVE: To quantify drug-induced changes in right ventricular (RV) systolic function after administration of pimobendan and atenolol.ANIMALS: 80 healthy privately-owned dogs.METHODS: Using a prospective, blinded, fully-crossed study design with randomized drug administration, RV systolic function was determined twice at two time periods; before and 3 h after administration of pimobendan (0.25 mg/kg PO) or atenolol (1 mg/kg PO). Indices of RV systolic function included tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC), pulsed-wave tissue Doppler-derived systolic myocardial velocity of the lateral tricuspid annulus (S'), and speckle-tracking-derived global longitudinal RV free wall strain and strain rate. The effect of treatment on percent change from baseline RV function was analyzed with a linear mixed model including the covariates heart rate, body weight, age, gender, drug sequence, and time period.RESULTS: All indices showed a significant (p < 0.0001) increase and decrease from baseline following pimobendan and atenolol, respectively. Significant differences from baseline were attributed to drug treatment (p < 0.0001); whereas, effects of other covariates were not significant. The greatest percent changes, but also highest variability, were observed for S' and strain rate (p < 0.0001). Post-atenolol, a significantly greater proportion of dogs exceeded the repeatability coefficient of variation for FAC and S' compared to TAPSE (p ≤ 0.007).CONCLUSIONS: Echocardiographic indices in healthy dogs tracked expected changes in RV systolic function following pimobendan and atenolol and warrant study in dogs with cardiovascular disease.",
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