Echocardiographic assessment of right ventricular systolic function in conscious healthy dogs: Repeatability and reference intervals

Lance C Visser, Brian A. Scansen, Karsten E. Schober, John D. Bonagura

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Objectives To determine the feasibility, repeatability, intra- and interobserver variability, and reference intervals for 5 echocardiographic indices of right ventricular (RV) systolic function: tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC), pulsed wave tissue Doppler imaging-derived systolic myocardial velocity of the lateral tricuspid annulus (S'), and speckle-tracking echocardiography-derived global longitudinal RV free wall strain and strain rate. To explore statistical relationships between RV systolic function and age, gender, heart rate, and bodyweight. Animals 80 healthy adult dogs. Methods Dogs underwent 2 echocardiographic examinations. Repeatability and intra-observer and inter-observer measurement variability were quantified by average coefficient of variation (CV). Relationships between RV function and age, heart rate and bodyweight were estimated by regression analysis. Results All indices were acquired with clinically acceptable repeatability and intra- and inter-observer variability (CVs < 10%). No differences were identified between male and female dogs. Allometric scaling by bodyweight demonstrated significant, clinically relevant correlations between RV function and bodyweight (all p ≤ 0.001) as follows: TAPSE - strong positive correlation (r;bsupesup&amp; = 0.75); S' - moderate positive correlation (r;bsupesup&amp; = 0.31); strain rate - moderate negative correlation (r;bsupesup& = 0.44); FAC and strain - weak negative correlations (r;bsupesup& = 0.22 and 0.14, respectively). Strain rate and FAC were positively correlated with heart rate (r;bsupesup& = 0.35 and 0.31, respectively). Allometric scaling generated bodyweight-based reference intervals for these RV systolic function indices. Conclusions Echocardiographic indices of RV systolic function are feasible to obtain, repeatable, and affected by bodyweight. Studies of these indices in dogs with cardiovascular disease are needed.

Original languageEnglish (US)
Pages (from-to)83-96
Number of pages14
JournalJournal of Veterinary Cardiology
Volume17
Issue number2
DOIs
StatePublished - Jun 1 2015
Externally publishedYes

Fingerprint

Right Ventricular Function
repeatability
Dogs
Observer Variation
body weight
dogs
heart rate
Heart Rate
echocardiography
cardiovascular diseases
Echocardiography
Cardiovascular Diseases
regression analysis
Regression Analysis
image analysis
gender
animals

Keywords

  • Canine
  • Cardiac
  • Reference range
  • Reproducibility
  • Right ventricle

ASJC Scopus subject areas

  • veterinary(all)
  • Physiology
  • Medicine(all)

Cite this

Echocardiographic assessment of right ventricular systolic function in conscious healthy dogs : Repeatability and reference intervals. / Visser, Lance C; Scansen, Brian A.; Schober, Karsten E.; Bonagura, John D.

In: Journal of Veterinary Cardiology, Vol. 17, No. 2, 01.06.2015, p. 83-96.

Research output: Contribution to journalArticle

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abstract = "Objectives To determine the feasibility, repeatability, intra- and interobserver variability, and reference intervals for 5 echocardiographic indices of right ventricular (RV) systolic function: tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC), pulsed wave tissue Doppler imaging-derived systolic myocardial velocity of the lateral tricuspid annulus (S'), and speckle-tracking echocardiography-derived global longitudinal RV free wall strain and strain rate. To explore statistical relationships between RV systolic function and age, gender, heart rate, and bodyweight. Animals 80 healthy adult dogs. Methods Dogs underwent 2 echocardiographic examinations. Repeatability and intra-observer and inter-observer measurement variability were quantified by average coefficient of variation (CV). Relationships between RV function and age, heart rate and bodyweight were estimated by regression analysis. Results All indices were acquired with clinically acceptable repeatability and intra- and inter-observer variability (CVs < 10{\%}). No differences were identified between male and female dogs. Allometric scaling by bodyweight demonstrated significant, clinically relevant correlations between RV function and bodyweight (all p ≤ 0.001) as follows: TAPSE - strong positive correlation (r;bsupesup& = 0.75); S' - moderate positive correlation (r;bsupesup& = 0.31); strain rate - moderate negative correlation (r;bsupesup& = 0.44); FAC and strain - weak negative correlations (r;bsupesup& = 0.22 and 0.14, respectively). Strain rate and FAC were positively correlated with heart rate (r;bsupesup& = 0.35 and 0.31, respectively). Allometric scaling generated bodyweight-based reference intervals for these RV systolic function indices. Conclusions Echocardiographic indices of RV systolic function are feasible to obtain, repeatable, and affected by bodyweight. Studies of these indices in dogs with cardiovascular disease are needed.",
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KW - Reference range

KW - Reproducibility

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