Abstract
Objectives To determine the feasibility, repeatability, intra- and interobserver variability, and reference intervals for 5 echocardiographic indices of right ventricular (RV) systolic function: tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC), pulsed wave tissue Doppler imaging-derived systolic myocardial velocity of the lateral tricuspid annulus (S'), and speckle-tracking echocardiography-derived global longitudinal RV free wall strain and strain rate. To explore statistical relationships between RV systolic function and age, gender, heart rate, and bodyweight. Animals 80 healthy adult dogs. Methods Dogs underwent 2 echocardiographic examinations. Repeatability and intra-observer and inter-observer measurement variability were quantified by average coefficient of variation (CV). Relationships between RV function and age, heart rate and bodyweight were estimated by regression analysis. Results All indices were acquired with clinically acceptable repeatability and intra- and inter-observer variability (CVs < 10%). No differences were identified between male and female dogs. Allometric scaling by bodyweight demonstrated significant, clinically relevant correlations between RV function and bodyweight (all p ≤ 0.001) as follows: TAPSE - strong positive correlation (r;bsupesup& = 0.75); S' - moderate positive correlation (r;bsupesup& = 0.31); strain rate - moderate negative correlation (r;bsupesup& = 0.44); FAC and strain - weak negative correlations (r;bsupesup& = 0.22 and 0.14, respectively). Strain rate and FAC were positively correlated with heart rate (r;bsupesup& = 0.35 and 0.31, respectively). Allometric scaling generated bodyweight-based reference intervals for these RV systolic function indices. Conclusions Echocardiographic indices of RV systolic function are feasible to obtain, repeatable, and affected by bodyweight. Studies of these indices in dogs with cardiovascular disease are needed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 83-96 |
| Number of pages | 14 |
| Journal | Journal of Veterinary Cardiology |
| Volume | 17 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 1 2015 |
| Externally published | Yes |
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Keywords
- Canine
- Cardiac
- Reference range
- Reproducibility
- Right ventricle
ASJC Scopus subject areas
- veterinary(all)
- Physiology
- Medicine(all)
Cite this
Echocardiographic assessment of right ventricular systolic function in conscious healthy dogs : Repeatability and reference intervals. / Visser, Lance C; Scansen, Brian A.; Schober, Karsten E.; Bonagura, John D.
In: Journal of Veterinary Cardiology, Vol. 17, No. 2, 01.06.2015, p. 83-96.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Echocardiographic assessment of right ventricular systolic function in conscious healthy dogs
T2 - Repeatability and reference intervals
AU - Visser, Lance C
AU - Scansen, Brian A.
AU - Schober, Karsten E.
AU - Bonagura, John D.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - Objectives To determine the feasibility, repeatability, intra- and interobserver variability, and reference intervals for 5 echocardiographic indices of right ventricular (RV) systolic function: tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC), pulsed wave tissue Doppler imaging-derived systolic myocardial velocity of the lateral tricuspid annulus (S'), and speckle-tracking echocardiography-derived global longitudinal RV free wall strain and strain rate. To explore statistical relationships between RV systolic function and age, gender, heart rate, and bodyweight. Animals 80 healthy adult dogs. Methods Dogs underwent 2 echocardiographic examinations. Repeatability and intra-observer and inter-observer measurement variability were quantified by average coefficient of variation (CV). Relationships between RV function and age, heart rate and bodyweight were estimated by regression analysis. Results All indices were acquired with clinically acceptable repeatability and intra- and inter-observer variability (CVs < 10%). No differences were identified between male and female dogs. Allometric scaling by bodyweight demonstrated significant, clinically relevant correlations between RV function and bodyweight (all p ≤ 0.001) as follows: TAPSE - strong positive correlation (r;bsupesup& = 0.75); S' - moderate positive correlation (r;bsupesup& = 0.31); strain rate - moderate negative correlation (r;bsupesup& = 0.44); FAC and strain - weak negative correlations (r;bsupesup& = 0.22 and 0.14, respectively). Strain rate and FAC were positively correlated with heart rate (r;bsupesup& = 0.35 and 0.31, respectively). Allometric scaling generated bodyweight-based reference intervals for these RV systolic function indices. Conclusions Echocardiographic indices of RV systolic function are feasible to obtain, repeatable, and affected by bodyweight. Studies of these indices in dogs with cardiovascular disease are needed.
AB - Objectives To determine the feasibility, repeatability, intra- and interobserver variability, and reference intervals for 5 echocardiographic indices of right ventricular (RV) systolic function: tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC), pulsed wave tissue Doppler imaging-derived systolic myocardial velocity of the lateral tricuspid annulus (S'), and speckle-tracking echocardiography-derived global longitudinal RV free wall strain and strain rate. To explore statistical relationships between RV systolic function and age, gender, heart rate, and bodyweight. Animals 80 healthy adult dogs. Methods Dogs underwent 2 echocardiographic examinations. Repeatability and intra-observer and inter-observer measurement variability were quantified by average coefficient of variation (CV). Relationships between RV function and age, heart rate and bodyweight were estimated by regression analysis. Results All indices were acquired with clinically acceptable repeatability and intra- and inter-observer variability (CVs < 10%). No differences were identified between male and female dogs. Allometric scaling by bodyweight demonstrated significant, clinically relevant correlations between RV function and bodyweight (all p ≤ 0.001) as follows: TAPSE - strong positive correlation (r;bsupesup& = 0.75); S' - moderate positive correlation (r;bsupesup& = 0.31); strain rate - moderate negative correlation (r;bsupesup& = 0.44); FAC and strain - weak negative correlations (r;bsupesup& = 0.22 and 0.14, respectively). Strain rate and FAC were positively correlated with heart rate (r;bsupesup& = 0.35 and 0.31, respectively). Allometric scaling generated bodyweight-based reference intervals for these RV systolic function indices. Conclusions Echocardiographic indices of RV systolic function are feasible to obtain, repeatable, and affected by bodyweight. Studies of these indices in dogs with cardiovascular disease are needed.
KW - Canine
KW - Cardiac
KW - Reference range
KW - Reproducibility
KW - Right ventricle
UR - http://www.scopus.com/inward/record.url?scp=84931009616&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84931009616&partnerID=8YFLogxK
U2 - 10.1016/j.jvc.2014.10.003
DO - 10.1016/j.jvc.2014.10.003
M3 - Article
C2 - 25547662
AN - SCOPUS:84931009616
VL - 17
SP - 83
EP - 96
JO - Journal of Veterinary Cardiology
JF - Journal of Veterinary Cardiology
SN - 1760-2734
IS - 2
ER -